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Review
. 2019 Dec;20(6):763-782.
doi: 10.1007/s10522-019-09837-y. Epub 2019 Sep 20.

D-Galactose-induced accelerated aging model: an overview

Khairunnuur Fairuz Azman  1 , Rahimah Zakaria  2
Affiliations
Review

D-Galactose-induced accelerated aging model: an overview

Khairunnuur Fairuz Azman et al. Biogerontology. 2019 Dec.

Abstract

To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and affordable anti-aging interventions are deemed necessary. Systemic administration of D-galactose has been established to artificially induce senescence in vitro and in vivo as well as for anti-aging therapeutic interventions studies. The aim of this article is to comprehensively discuss the use of D-galactose to generate a model of accelerated aging and its possible underlying mechanisms involved in different tissues/organs.

Keywords: Aging model; Anti-aging; D-Galactose; Senescence.

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