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Observational Study
. 2020 Aug 14;71(4):1089-1091.
doi: 10.1093/cid/ciz904.

Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study

Sylvie Behillil  1 , Faten May  2   3 , Slim Fourati  4 , Charles-Edouard Luyt  5 , Thomas Chicheportiche  5 , Romain Sonneville  6 , Yacine Tandjaoui-Lambiotte  7 , Damien Roux  8 , Laurent Guérin  9 , Julien Mayaux  10 , Eric Maury  11 , Alexis Ferré  12 , Jean-François Georger  13 , Guillaume Voiriot  14 , Vincent Enouf  1 , Sylvie van der Werf  1 , Armand Mekontso Dessap  2   3 , Nicolas de Prost  2   3
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Observational Study

Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study

Sylvie Behillil et al. Clin Infect Dis. .

Abstract

In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day 28 mortality than others (80% vs 12%; P = .011).

Keywords: H1N1 subtype; adult; influenza A virus; oseltamivir; pneumonia; respiratory distress syndrome; viral.

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