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Comment
. 2019 Nov 4;21(11):1341-1343.
doi: 10.1093/neuonc/noz165.

Understanding a complicated Gal-1

Angela C Hirbe  1 , David H Gutmann  2
Affiliations
Comment

Understanding a complicated Gal-1

Angela C Hirbe et al. Neuro Oncol. .
No abstract available

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Figures

Fig. 1
Fig. 1
Autocrine and paracrine effects of galectin-1. As an intracellular scaffold protein, galectin-1 stabilizes Ras and Ras effector interactions, leading to more efficient Ras activation and greater tumor cell growth. In addition, galectin-1 increases CXCR4 expression, which further enhances chemokine (CXCL12)-mediated cell survival. As a paracrine factor, galectin-1 production by tumor cells reprograms non-neoplastic (stromal) cells in the tumor microenvironment, including T cells (immune regulation), endothelial cells (angiogenesis), and other cells types (e.g., macrophages) to secrete mitogens and chemokines that increase Ras and Ras effector (MEK) activation through receptor tyrosine kinase (RTK) and G protein-coupled receptor (chemokine) receptors (e.g., CXCR4), respectively.
See this image and copyright information in PMC

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References

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