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. 2019 Nov;41(1):770-777.
doi: 10.1080/0886022X.2019.1650065.

Relationship of matrix Gla protein and vitamin K with vascular calcification in hemodialysis patients

Sonoo Mizuiri  1 , Yoshiko Nishizawa  1 , Kazuomi Yamashita  1 , Kyoka Ono  1 , Takayuki Naito  2 , Chie Tanji  3 , Koji Usui  3 , Shigehiro Doi  4 , Takao Masaki  4 , Kenichiro Shigemoto  1
Affiliations

Relationship of matrix Gla protein and vitamin K with vascular calcification in hemodialysis patients

Sonoo Mizuiri et al. Ren Fail. 2019 Nov.

Abstract

Objective: This study evaluated associations of serum matrix Gla protein (MGP), plasma vitamin K1, and plasma vitamin K2 with coronary artery calcium score (CACS) and cardiovascular disease (CVD) in maintenance hemodialysis (MHD) patients. Methods: Subjects comprised 112 MHD patients aged 30-60 years and 40 age-matched healthy subjects. Total MGP, vitamin K1, vitamin K2, and lipid profile were examined in all subjects; other clinical data, medication use, and CACS were assessed only in MHD patients. Determinants of MGP in all subjects were identified by regression analysis. Factors associated with CACS and CVD in MHD patients were identified by regression analysis and logistic analysis, respectively. Results: Lower plasma levels of vitamin K1 corrected for triglycerides [0.39 (0.24-0.70) vs. 0.77 (0.48-1.34) ng/mg, p < 0.001], higher frequency of plasma vitamin K2 ≤ 0.05 ng/ml (p = 0.23), and higher serum total MGP (288.4 ± 44.2 vs. 159.7 ± 40.6 ng/ml, p < 0.0001) were observed in MHD patients than in healthy controls. Total MGP level was significantly associated with levels of vitamin K1 corrected for triglycerides (p <0 .001) and vitamin K2 ≤ 0.05 ng/ml (p < 0.05) in all subjects. Total MGP level was significantly associated with presence of CVD (p <0 .05), but not CACS, in MHD patients. Conclusion: The end-stage renal disease on hemodialysis is a deficiency state of vitamin K. Total MGP was significantly higher in MHD patients compared to healthy subjects and total MGP was associated with the presence of CVD, but not CACS, in MHD patients.

Keywords: Cardiovascular disease; coronary artery calcium score; hemodialysis; matrix Gla protein; vitamins K.

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Figures

Figure 1.
Figure 1.
Plasma vitamin K1 levels corrected for triglycerides in hemodialysis patients and healthy controls.
Figure 2.
Figure 2.
Serum matrix Gla protein levels in hemodialysis patients and healthy controls.
See this image and copyright information in PMC

References

    1. Price PA, Urist MR, Otawara Y. Matrix Gla protein, a new gamma-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone. Biochem Biophys Res Commun. 1983;117:765–771. - PubMed
    1. Wuyts J, Dhondt A. The role of vitamin K in vascular calcification of patients with chronic kidney disease. Acta Clin Belg. 2016;71:462–467. - PubMed
    1. Barrett H, O’Keeffe M, Kavanagh E, et al. . Is matrix Gla protein associated with vascular calcification? A systematic review. Nutrients. 2018;10:E415. - PMC - PubMed
    1. Fusaro M, Plebani M, Iervasi G, et al. . Vitamin K deficiency in chronic kidney disease: evidence is building up. Am J Nephrol. 2017;45:1–3. - PubMed
    1. Cheung CL, Sahni S, Cheung BM, et al. . Vitamin K intake and mortality in people with chronic kidney disease from NHANES III. Clin Nutr. 2015;34:235–240. - PubMed

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