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Meta-Analysis
. 2019 Sep 20;9(1):13626.
doi: 10.1038/s41598-019-50135-x.

Dengue virus infection in people residing in Africa: a systematic review and meta-analysis of prevalence studies

Fredy Brice N Simo  1   2 , Jean Joel Bigna  3 , Sebastien Kenmoe  1 , Marie S Ndangang  4 , Elvis Temfack  5 , Paul F Moundipa  2 , Maurice Demanou  6
Affiliations
Meta-Analysis

Dengue virus infection in people residing in Africa: a systematic review and meta-analysis of prevalence studies

Fredy Brice N Simo et al. Sci Rep. .

Abstract

Better knowledge of the face of the current dengue virus (DENV) epidemiology in Africa can help to implement efficient strategies to curb the burden of dengue fever. We conducted this systematic review and meta-analysis to determine the prevalence of DENV infection in Africa. We searched PubMed, EMBASE, African Journals Online, and Africa Index Medicus from January 1st, 2000 to June 10th, 2019 without any language restriction. We used a random-effects model to pool studies. A total of 76 studies (80,977 participants; 24 countries) were included. No study had high risk of bias. Twenty-two (29%) had moderate and 54 (71%) had low risk of bias. In apparently healthy individuals, the pooled prevalence of DENV was 15.6% (95% confidence interval 9.9-22.2), 3.5% (0.8-7.8), and 0.0% (0.0-0.5) respectively for immunoglobulins (Ig) G, IgM, and for ribonucleic acid (RNA) in apparently healthy populations. In populations presenting with fever, the prevalence was 24.8% (13.8-37.8), 10.8% (3.8-20.6k) and 8.4% (3.7-14.4) for IgG, IgM, and for RNA respectively. There was heterogeneity in the distribution between different regions of Africa. The prevalence of DENV infection is high in the African continent. Dengue fever therefore deserves more attention from healthcare workers, researchers, and health policy makers.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Study selection process.
Figure 2
Figure 2
Meta-analysis of immunoglobulins G seroprevalence of Dengue virus in Africa.
Figure 3
Figure 3
Meta-analysis of immunoglobulins M seroprevalence of Dengue virus in Africa.
Figure 4
Figure 4
Meta-analysis prevalence of Dengue virus ribonucleic acid in Africa.
See this image and copyright information in PMC

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