Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Oct;60(10):1014-1020.
doi: 10.1007/s00108-019-00675-1.

[Directed evolution in drug and antibody development : From the Nobel Prize to broad clinical application]

[Article in German]
A G Beck-Sickinger  1
Affiliations
Review

[Directed evolution in drug and antibody development : From the Nobel Prize to broad clinical application]

[Article in German]
A G Beck-Sickinger. Internist (Berl). 2019 Oct.

Abstract

Combinatorial procedures have become established in recent years as alternatives to rational design in drug research, particularly when no structural information is available. This article presents the principle that was originally developed by three scientists and was honored with the Nobel Prize for Chemistry in 2018. Furthermore, the application in the field of monclonal antibodies is discussed.

Keywords: Antibodies, monoclonal; Combinatorial chemistry techniques; Molecular biology; Nobel Prize in Chemistry 2018; Phage display.

PubMed Disclaimer

References

    1. Science. 1990 Jul 27;249(4967):386-90 - PubMed
    1. Clin Cancer Res. 2007 Oct 1;13(19):5889-96 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6378-82 - PubMed
    1. Curr Opin Pharmacol. 2012 Oct;12(5):615-22 - PubMed
    1. MAbs. 2015;7(1):9-14 - PubMed

Substances

Personal name as subject

LinkOut - more resources