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Randomized Controlled Trial
. 2020 Apr 1;33(4):362-370.
doi: 10.1093/ajh/hpz148.

Reducing Hypertension in a Poststroke Black and Hispanic Home Care Population: Results of a Pragmatic Randomized Controlled Trial

Penny H Feldman  1 , Margaret V McDonald  1 , Melissa Trachtenberg  1 , Marygrace Trifilio  1 , Nicole Onorato  1 , Sridevi Sridharan  1 , Stephanie Silver  2 , Joseph Eimicke  2 , Jeanne Teresi  2   3
Affiliations
Randomized Controlled Trial

Reducing Hypertension in a Poststroke Black and Hispanic Home Care Population: Results of a Pragmatic Randomized Controlled Trial

Penny H Feldman et al. Am J Hypertens. .

Abstract

Background: Uncontrolled hypertension (HTN) is a leading modifiable stroke risk factor contributing to global stroke disparities. This study is unique in testing a transitional care model aimed at controlling HTN in black and Hispanic poststroke, home health patients, an understudied group.

Methods: A 3-arm randomized controlled trial design compared (i) usual home care (UHC), with (ii) UHC plus a 30-day nurse practitioner transitional care program, or (iii) UHC plus nurse practitioner plus a 60-day health coach program. The trial enrolled 495 black and Hispanic, English- and Spanish- speaking adults with uncontrolled systolic blood pressure (SBP ≥ 140 mm Hg) who had experienced a first-time or recurrent stroke or transient ischemic attack. The primary outcome was change in SBP from baseline to 3 and 12 months.

Results: Mean participant age was 67; 57.0% were female; 69.7% were black, non-Hispanic; and 30.3% were Hispanic. Three-month follow-up retention was 87%; 12-month retention was 81%. SBP declined 9-10 mm Hg from baseline to 12 months across all groups; the greatest decrease occurred between baseline and 3 months. The interventions demonstrated no relative advantage compared to UHC.

Conclusion: The significant across-the-board SBP decreases suggest that UHC nurse/patient/physician interactions were the central component of SBP reduction and that additional efforts to lower recurrent stroke risk should test incremental improvements in usual care, not resource-intensive transitional care interventions. They also suggest the potential value of pragmatic home care programs as part of a broader strategy to overcome HTN treatment barriers and improve secondary stroke prevention globally.

Clinical trials registration: Trial Number NCT01918891.

Keywords: blood pressure; hypertension; nurse practitioner; randomized controlled trial; stroke.

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Figures

Figure 1.
Figure 1.
CONSORT diagram. Abbreviations: BP, blood pressure; HC, health coach; NP, nurse practitioner; UHC; usual home care.
Figure 2.
Figure 2.
Observed means and SDs for systolic blood pressure (SBP) in mm Hg over time by randomization group (n = 495) demonstrating a significant within-group decrease in SBP from baseline to the 2 follow-up points but no differences in SBP decline between randomized groups.
See this image and copyright information in PMC

Comment in

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