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Review
. 2020;29(1):1-5.
doi: 10.1159/000503575. Epub 2019 Sep 23.

Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma

Ilgin Yildirim Simsir  1 , Sevki Cetinkalp  2 , Taylan Kabalak  2
Affiliations
Review

Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma

Ilgin Yildirim Simsir et al. Med Princ Pract. 2020.

Abstract

There is an increased incidence of thyroid nodules and cancer. In this article, the reasons for this increase are evaluated and discussed. The factors causing increases in the incidence of nodules are the same as those causing increases in thyroid cancer. There are publications from all over the world regarding the rising incidence of thyroid cancer; it is especially associated with papillary cancer. The literature was reviewed and evaluated with regard to this significant phenomenon. Thyroid-stimulating hormone (TSH) is the main mitotic factor. Any agent that elevates TSH will stimulate nodule formation. Therefore, the incidence of thyroid nodules is high in endemic goiter regions due to iodine deficiency. This paper has described many of the factors causing this higher incidence. Of note, metabolic syndrome and insulin resistance are important factors associated with the increased incidence of nodular goiter and papillary thyroid cancer today. However, these data must be confirmed by other studies in the future.

Keywords: Nodular goiter; Thyroid cancer.

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Conflict of interest statement

The authors declare no potential conflicts of interest.

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References

    1. Studer H, Peter HJ, Gerber H. Natural heterogeneity of thyroid cells: the basis for understanding thyroid function and nodular goiter growth. Endocr Rev. 1989 May;10((2)):125–35. - PubMed
    1. Pellegriti G, Frasca F, Regalbuto C, Squatrito S, Vigneri R. Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol. 2013;2013:965212. - PMC - PubMed
    1. Jiang H, Tian Y, Yan W, Kong Y, Wang H, Wang A, et al. The Prevalence of Thyroid Nodules and an Analysis of Related Lifestyle Factors in Beijing Communities. Int J Environ Res Public Health. 2016 Apr;13((4)):442. - PMC - PubMed
    1. Popoveniuc G, Jonklaas J. Thyroid nodules. Med Clin North Am. 2012 Mar;96((2)):329–49. - PMC - PubMed
    1. Iglesias ML, Schmidt A, Ghuzlan AA, Lacroix L, Vathaire F, Chevillard S, et al. Radiation exposure and thyroid cancer: a review. Arch Endocrinol Metab. 2017 Mar-Apr;61((2)):180–7. - PMC - PubMed