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Comment
. 2019 Oct;139(10):2075-2077.
doi: 10.1016/j.jid.2019.05.027.

PLCD1 and Pilar Cysts

Yutaka Shimomura  1 , Ryan O'Shaughnessy  2 , Neil Rajan  3
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Free article
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PLCD1 and Pilar Cysts

Yutaka Shimomura et al. J Invest Dermatol. 2019 Oct.
Free article

Abstract

Trichilemmal or "pilar" cysts are commonly found on the scalp and are derived from the outer root sheath of the hair follicle. Multiple trichilemmal cysts present in an autosomal dominant pattern of inheritance, yet the genetic mechanism has remained elusive. In this issue, Hörer et al. (2019) highlight predisposing variants in PLCD1 in such families and propose a monoallelic mutational mechanism that drives cyst formation.

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