Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

doi:10.1016/j.cmet.2019.08.018

. 2019 Oct 1;30(4):675-688.e7.

doi: 10.1016/j.cmet.2019.08.018. Epub 2019 Sep 19.

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

Jing Yuan¹, Chen Chen², Jinghua Cui³, Jing Lu⁴, Chao Yan³, Xiao Wei⁴, Xiangna Zhao⁴, NanNan Li³, Shaoli Li³, Guanhua Xue³, Weiwei Cheng⁴, Boxing Li⁴, Huan Li⁴, Weishi Lin⁴, Changyu Tian⁴, Jiangtao Zhao⁴, Juqiang Han⁵, Daizhi An⁴, Qiong Zhang², Hong Wei⁶, Minghua Zheng⁷, Xuejun Ma⁸, Wei Li⁹, Xiao Chen³, Zheng Zhang³, Hui Zeng², Sun Ying¹⁰, JianXin Wu³, Ruifu Yang¹¹, Di Liu¹²

Affiliations

¹ Capital Institute of Pediatrics, Beijing 100020, China; Chinese PLA Center for Disease Control and Prevention, Beijing 100071, China. Electronic address: yuanjing6216@163.com.
² Beijing key laboratory of emerging infectious diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
³ Capital Institute of Pediatrics, Beijing 100020, China.
⁴ Chinese PLA Center for Disease Control and Prevention, Beijing 100071, China.
⁵ Institute of Hepatology, PLA Army General Hospital, Beijing 100700, China.
⁶ College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China.
⁷ NAFLD Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.
⁸ National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
⁹ Computational Virology Group, Center for Bacteria and Virus Resources and Application, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 101408, China; Institue of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
¹⁰ Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
¹¹ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. Electronic address: 13801034560@163.com.
¹² Computational Virology Group, Center for Bacteria and Virus Resources and Application, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 101408, China. Electronic address: liud@wh.iov.cn.

PMID: 31543403
DOI: 10.1016/j.cmet.2019.08.018

Free article

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

Jing Yuan et al. Cell Metab. 2019.

Free article

. 2019 Oct 1;30(4):675-688.e7.

doi: 10.1016/j.cmet.2019.08.018. Epub 2019 Sep 19.

Authors

Affiliations

¹ Capital Institute of Pediatrics, Beijing 100020, China; Chinese PLA Center for Disease Control and Prevention, Beijing 100071, China. Electronic address: yuanjing6216@163.com.
² Beijing key laboratory of emerging infectious diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
³ Capital Institute of Pediatrics, Beijing 100020, China.
⁴ Chinese PLA Center for Disease Control and Prevention, Beijing 100071, China.
⁵ Institute of Hepatology, PLA Army General Hospital, Beijing 100700, China.
⁶ College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China.
⁷ NAFLD Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.
⁸ National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
⁹ Computational Virology Group, Center for Bacteria and Virus Resources and Application, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 101408, China; Institue of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
¹⁰ Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
¹¹ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. Electronic address: 13801034560@163.com.
¹² Computational Virology Group, Center for Bacteria and Virus Resources and Application, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing 101408, China. Electronic address: liud@wh.iov.cn.

PMID: 31543403
DOI: 10.1016/j.cmet.2019.08.018

Erratum in

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae.
Yuan J, Chen C, Cui J, Lu J, Yan C, Wei X, Zhao X, Li N, Li S, Xue G, Cheng W, Li B, Li H, Lin W, Tian C, Zhao J, Han J, An D, Zhang Q, Wei H, Zheng M, Ma X, Li W, Chen X, Zhang Z, Zeng H, Ying S, Wu J, Yang R, Liu D. Yuan J, et al. Cell Metab. 2019 Dec 3;30(6):1172. doi: 10.1016/j.cmet.2019.11.006. Cell Metab. 2019. PMID: 31801057 No abstract available.

Abstract

The underlying etiology of nonalcoholic fatty liver disease (NAFLD) is believed to be quite varied. Changes in the gut microbiota have been investigated and are believed to contribute to at least some cases of the disease, though a causal relationship remains unclear. Here, we show that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) is associated with up to 60% of individuals with NAFLD in a Chinese cohort. Transfer of clinical isolates of HiAlc Kpn by oral gavage into mice induced NAFLD. Likewise, fecal microbiota transplant (FMT) into mice using a HiAlc-Kpn-strain-containing microbiota isolated from an individual with NASH induced NAFLD. However, selective elimination of the HiAlc Kpn strain before FMT prevented NAFLD in the recipient mice. These results suggest that at least in some cases of NAFLD an alteration in the gut microbiome drives the condition due to excess endogenous alcohol production.

Keywords: Klebsiella pneumoniae; alcohol-producing bacteria; endo-NAFLD; fatty liver disease; fecal microbiota transplantation; gut microbiota; high-fat diet; liver transcriptome; metagenomics; mice model.

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Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

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Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

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