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Review
. 2019 Aug 30:10:1055.
doi: 10.3389/fpls.2019.01055. eCollection 2019.

DNA Base Excision Repair in Plants: An Unfolding Story With Familiar and Novel Characters

Teresa Roldán-Arjona  1   2   3 , Rafael R Ariza  1   2   3 , Dolores Córdoba-Cañero  1   2   3
Affiliations
Review

DNA Base Excision Repair in Plants: An Unfolding Story With Familiar and Novel Characters

Teresa Roldán-Arjona et al. Front Plant Sci. .

Abstract

Base excision repair (BER) is a critical genome defense pathway that deals with a broad range of non-voluminous DNA lesions induced by endogenous or exogenous genotoxic agents. BER is a complex process initiated by the excision of the damaged base, proceeds through a sequence of reactions that generate various DNA intermediates, and culminates with restoration of the original DNA structure. BER has been extensively studied in microbial and animal systems, but knowledge in plants has lagged behind until recently. Results obtained so far indicate that plants share many BER factors with other organisms, but also possess some unique features and combinations. Plant BER plays an important role in preserving genome integrity through removal of damaged bases. However, it performs additional important functions, such as the replacement of the naturally modified base 5-methylcytosine with cytosine in a plant-specific pathway for active DNA demethylation.

Keywords: AP endonuclease; Arabidopsis; DNA damage; DNA glycosylase; DNA repair.

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Figures

Figure 1
Figure 1
Schematic representation of the base excision repair (BER) pathway. See text for details.
See this image and copyright information in PMC

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References

    1. Agius F., Kapoor A., Zhu J. K. (2006). Role of the Arabidopsis DNA glycosylase/lyase ROS1 in active DNA demethylation. Proc. Natl. Acad. Sci. U.S.A. 103 (31), 11796–11801. 10.1073/pnas.0603563103 - DOI - PMC - PubMed
    1. Akbari M., Solvang-Garten K., Hanssen-Bauer A., Lieske N. V., Pettersen H. S., Pettersen G. K., et al. (2010). Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair (Amst.) 9 (7), 785–795. 10.1016/j.dnarep.2010.04.002 - DOI - PMC - PubMed
    1. Akishev Z., Taipakova S., Joldybayeva B., Zutterling C., Smekenov I., Ishchenko A. A., et al. (2016). The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP is involved in the plant nucleotide incision repair pathway. DNA Repair (Amst.) 48, 30–42. 10.1016/j.dnarep.2016.10.009 - DOI - PubMed
    1. Almendral J. M., Huebsch D., Blundell P. A., Macdonald-Bravo H., Bravo R. (1987). Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 84 (6), 1575–1579. 10.1073/pnas.84.6.1575 - DOI - PMC - PubMed
    1. Allinson S. L., Dianova I. I., Dianov G. L. (2003). Poly (ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing. Acta Biochim. Pol.-Engl. Ed. 50 (1), 169–180. 10.1111/j.1742-4658.2005.04628.x - DOI - PubMed