The proposed Drug Resistance Index (DRI) is not a good measure of antibiotic effectiveness in relation to drug resistance

Affiliations

¹ Medical Microbiology & Infection Control, Amsterdam UMC - Locatie VUMC, Amsterdam, The Netherlands.
² The EUCAST Development Laboratory and Clinical Microbiology, Central Hospital in Vaxjo, Vaxjo, Sweden.
³ Julius Center for Health Sciences and Primary Care, University Medical Centre, Utrecht, The Netherlands.
⁴ Department of Infection Control, Amphia Hospital, Breda, The Netherlands.
⁵ Office of the Chief Scientist, European Centre for Disease Prevention and Control, Solna, Sweden.
⁶ Department of Clinical Microbiology, University Hospital of North Norway, UiT Arctic University of Norway, Tromso, Norway.
⁷ Division of Infectious Disease Preparedness, Statens Serum Institut, Kobenhavn, Denmark.
⁸ Reference Laboratory for Antimicrobial Resistance, Infection Preparedness, Statens Serum Institut, Kobenhavn, Denmark.
⁹ Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands.
¹⁰ Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

Comment

Christina M J E Vandenbroucke-Grauls et al. BMJ Glob Health. 2019.

. 2019 Aug 21;4(4):e001838.

doi: 10.1136/bmjgh-2019-001838. eCollection 2019.

¹ Medical Microbiology & Infection Control, Amsterdam UMC - Locatie VUMC, Amsterdam, The Netherlands.
² The EUCAST Development Laboratory and Clinical Microbiology, Central Hospital in Vaxjo, Vaxjo, Sweden.
³ Julius Center for Health Sciences and Primary Care, University Medical Centre, Utrecht, The Netherlands.
⁴ Department of Infection Control, Amphia Hospital, Breda, The Netherlands.
⁵ Office of the Chief Scientist, European Centre for Disease Prevention and Control, Solna, Sweden.
⁶ Department of Clinical Microbiology, University Hospital of North Norway, UiT Arctic University of Norway, Tromso, Norway.
⁷ Division of Infectious Disease Preparedness, Statens Serum Institut, Kobenhavn, Denmark.
⁸ Reference Laboratory for Antimicrobial Resistance, Infection Preparedness, Statens Serum Institut, Kobenhavn, Denmark.
⁹ Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands.
¹⁰ Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

No abstract available

Keywords: Drug Resistance Index; antibiotic use; antimicrobial resistance.

Conflict of interest statement

Competing interests: None declared.

Tracking global trends in the effectiveness of antibiotic therapy using the Drug Resistance Index.
Klein EY, Tseng KK, Pant S, Laxminarayan R. Klein EY, et al. BMJ Glob Health. 2019 Apr 11;4(2):e001315. doi: 10.1136/bmjgh-2018-001315. eCollection 2019. BMJ Glob Health. 2019. PMID: 31139449 Free PMC article.

1. Available: https://www.who.int/antimicrobial-resistance/publications/global-action-...
1. Available: http://www.un.org/pga/71/2016/09/21/press-release-hl-meeting-on-antimicr...
1. Klein EY, Tseng KK, Pant S, et al. . Tracking global trends in the effectiveness of antibiotic therapy using the drug resistance index. BMJ Glob Health 2019;4:e001315 10.1136/bmjgh-2018-001315 - DOI - PMC - PubMed
1. Laxminarayan R, Klugman KP. Communicating trends in resistance using a drug resistance index. BMJ Open 2011;1:e000135 10.1136/bmjopen-2011-000135 - DOI - PMC - PubMed
1. European Centre for Diseases Prevention and Control Antimicrobial consumption -Annual epidemiological report for 2017; 2017. Available: https://www.ecdc.europa.eu/sites/portal/files/documents/AER_for_2017-ant....