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. 2021 Jul;35(13):2211-2217.
doi: 10.1080/14786419.2019.1667352. Epub 2019 Sep 23.

A new isoflavanone from Uraria crinita

Dao Duc Thien  1 , Trinh Thi Thuy  1   2 , Nguyen Thi Hoang Anh  1   2 , Le Quoc Thang  3 , Tran Duc Dai  4 , Nguyen Hoang Sa  5 , Nguyen Thanh Tam  1   2
Affiliations

A new isoflavanone from Uraria crinita

Dao Duc Thien et al. Nat Prod Res. 2021 Jul.

Abstract

A new isoflavanone, (3S)-5,7-dihydroxy-2',3',4'-trimethoxy-6,5'-diprenylisoflavanone (1) and eight known compounds including five flavones (2-6), two triterpenes (7-8) and a steroid (9) were isolated from the whole plant of Uraria crinita (Leguminosae). The structure of 1 was elucidated by detailed spectroscopic means including IR, HR-ESI-MS, 1D and 2D NMR, and CD data. Compounds 1-9 were evaluated for their cytotoxicity against four human cancer cell lines KB (mouth epidermal carcinoma), HepG2 (hepatocellular carcinoma), Lu (lung carcinoma) and MCF7 (breast carcinoma). Compound 1 showed cytotoxic activity against the tested cell lines with IC50 values of 33.2, 29.4, 59.6 and 66.8 μM, respectively.

Keywords: (3S)-5,7-dihydroxy-2′,3′,4′-trimethoxy-6,5′-diprenylisoflavanone; Leguminosae; Uraria crinita; cytotoxicity.

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