New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease

doi:10.3390/ijerph16193546

Review

. 2019 Sep 22;16(19):3546.

doi: 10.3390/ijerph16193546.

New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease

Airton Cunha Martins Jr¹, Patricia Morcillo², Omamuyovwi Meashack Ijomone³, Vivek Venkataramani⁴, Fiona Edith Harrison⁵, Eunsook Lee⁶, Aaron Blaine Bowman⁷, Michael Aschner⁸

Affiliations

¹ Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
² Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. patricia.morcillo@einstein.yu.edu.
³ Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology Akure, Akure 340252, Nigeria. godmamus@gmail.com.
⁴ Department of Hematology and Medical Oncology and Institute of Pathology, University Medical Center Göttingen (UMG), 37075 Göttingen, Germany. ramani@med.uni-goettingen.de.
⁵ Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. fiona.harrison@Vanderbilt.Edu.
⁶ Department of Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32301, USA. eunsook.lee@famu.edu.
⁷ School of Health Sciences, Purdue University, West Lafayette, IN 47907-2051, USA. bowma117@purdue.edu.
⁸ Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. michael.aschner@einstein.yu.edu.

PMID: 31546716
PMCID: PMC6801377
DOI: 10.3390/ijerph16193546

Review

New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease

Airton Cunha Martins Jr et al. Int J Environ Res Public Health. 2019.

. 2019 Sep 22;16(19):3546.

doi: 10.3390/ijerph16193546.

Authors

Airton Cunha Martins Jr¹, Patricia Morcillo², Omamuyovwi Meashack Ijomone³, Vivek Venkataramani⁴, Fiona Edith Harrison⁵, Eunsook Lee⁶, Aaron Blaine Bowman⁷, Michael Aschner⁸

Affiliations

¹ Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
² Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. patricia.morcillo@einstein.yu.edu.
³ Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology Akure, Akure 340252, Nigeria. godmamus@gmail.com.
⁴ Department of Hematology and Medical Oncology and Institute of Pathology, University Medical Center Göttingen (UMG), 37075 Göttingen, Germany. ramani@med.uni-goettingen.de.
⁵ Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. fiona.harrison@Vanderbilt.Edu.
⁶ Department of Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32301, USA. eunsook.lee@famu.edu.
⁷ School of Health Sciences, Purdue University, West Lafayette, IN 47907-2051, USA. bowma117@purdue.edu.
⁸ Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. michael.aschner@einstein.yu.edu.

PMID: 31546716
PMCID: PMC6801377
DOI: 10.3390/ijerph16193546

Abstract

Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer's disease (AD) and Parkinson's disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.

Keywords: Alzheimer’s disease; Parkinson’s disease; manganese; neurodegeneration.

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Conflict of interest statement

The authors declare no conflicts of interest.

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References

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1. Fitsanakis V.A., Au C., Erikson K.M., Aschner M. The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation. Neurochem. Int. 2006;48:426–433. doi: 10.1016/j.neuint.2005.10.012. - DOI - PubMed
1. Chen Y., Shen Y., Wang W., Wei D. Mn2+ modulates the expression of cellulase genes in Trichoderma reesei Rut-C30 via calcium signaling. Biotechnol. Biofuels. 2018;11:54. doi: 10.1186/s13068-018-1055-6. - DOI - PMC - PubMed
1. Wang C., Guan Y., Lv M., Zhang R., Guo Z., Wei X., Du X., Yang J., Li T., Wan Y., et al. Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses. Immunity. 2018;48:675–687. doi: 10.1016/j.immuni.2018.03.017. - DOI - PubMed

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[1] Hood M.I., Skaar E.P. Nutritional immunity: Transition metals at the pathogen-host interface. Nat. Rev. Microbiol. 2012;10:525. doi: 10.1038/nrmicro2836. - DOI - PMC - PubMed

[2] Hood M.I., Skaar E.P. Nutritional immunity: Transition metals at the pathogen-host interface. Nat. Rev. Microbiol. 2012;10:525. doi: 10.1038/nrmicro2836. - DOI - PMC - PubMed

[3] Andreini C., Bertini I., Cavallaro G., Holliday G.L., Thornton J.M. Metal ions in biological catalysis: From enzyme databases to general principles. J. Biol. Inorg. Chem. 2008;13:1205–1218. doi: 10.1007/s00775-008-0404-5. - DOI - PubMed

[4] Andreini C., Bertini I., Cavallaro G., Holliday G.L., Thornton J.M. Metal ions in biological catalysis: From enzyme databases to general principles. J. Biol. Inorg. Chem. 2008;13:1205–1218. doi: 10.1007/s00775-008-0404-5. - DOI - PubMed

[5] Fitsanakis V.A., Au C., Erikson K.M., Aschner M. The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation. Neurochem. Int. 2006;48:426–433. doi: 10.1016/j.neuint.2005.10.012. - DOI - PubMed

[6] Fitsanakis V.A., Au C., Erikson K.M., Aschner M. The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation. Neurochem. Int. 2006;48:426–433. doi: 10.1016/j.neuint.2005.10.012. - DOI - PubMed

[7] Chen Y., Shen Y., Wang W., Wei D. Mn2+ modulates the expression of cellulase genes in Trichoderma reesei Rut-C30 via calcium signaling. Biotechnol. Biofuels. 2018;11:54. doi: 10.1186/s13068-018-1055-6. - DOI - PMC - PubMed

[8] Chen Y., Shen Y., Wang W., Wei D. Mn2+ modulates the expression of cellulase genes in Trichoderma reesei Rut-C30 via calcium signaling. Biotechnol. Biofuels. 2018;11:54. doi: 10.1186/s13068-018-1055-6. - DOI - PMC - PubMed

[9] Wang C., Guan Y., Lv M., Zhang R., Guo Z., Wei X., Du X., Yang J., Li T., Wan Y., et al. Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses. Immunity. 2018;48:675–687. doi: 10.1016/j.immuni.2018.03.017. - DOI - PubMed

[10] Wang C., Guan Y., Lv M., Zhang R., Guo Z., Wei X., Du X., Yang J., Li T., Wan Y., et al. Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses. Immunity. 2018;48:675–687. doi: 10.1016/j.immuni.2018.03.017. - DOI - PubMed

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New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease

Affiliations

New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease

Authors

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Abstract

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Abstract

Conflict of interest statement

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