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. 2019 Sep 20;9(10):1349.
doi: 10.3390/nano9101349.

Mono-6-Deoxy-6-Aminopropylamino- β-Cyclodextrin on Ag-Embedded SiO2 Nanoparticle as a Selectively Capturing Ligand to Flavonoids

Eunil Hahm  1 , Eun Ji Kang  2 , Xuan-Hung Pham  3 , Daham Jeong  4 , Dae Hong Jeong  5 , Seunho Jung  6 , Bong-Hyun Jun  7
Affiliations

Mono-6-Deoxy-6-Aminopropylamino- β-Cyclodextrin on Ag-Embedded SiO2 Nanoparticle as a Selectively Capturing Ligand to Flavonoids

Eunil Hahm et al. Nanomaterials (Basel). .

Abstract

It has been increasingly important to develop a highly sensitive and selective technique that is easy to handle in detecting levels of beneficial or hazardous analytes in trace quantity. In this study, mono-6-deoxy-6-aminopropylamino-β-cyclodextrin (pr-β-CD)-functionalized silver-assembled silica nanoparticles (SiO2@Ag@pr-β-CD) for flavonoid detection were successfully prepared. The presence of pr-β-CD on the surface of SiO2@Ag enhanced the selectivity in capturing quercetin and myricetin among other similar materials (naringenin and apigenin). In addition, SiO2@Ag@pr-β-CD was able to detect quercetin corresponding to a limit of detection (LOD) as low as 0.55 ppm. The relationship between the Raman intensity of SiO2@Ag@pr-β-CD and the logarithm of the Que concentration obeyed linearity in the range 3.4-33.8 ppm (R2 = 0.997). The results indicate that SiO2@Ag@pr-β-CD is a promising material for immediately analyzing samples that demand high sensitivity and selectivity of detection.

Keywords: Ag-embedded SiO2; SERS; flavonoid; mono-6-deoxy-6-aminopropylamino-β-cyclodextrin; pr-β-CD; selectivity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Schematic illustration of the effects of pr-β-CD on the surface of SiO2@Ag in selective flavonoid detection.
Figure 1
Figure 1
(a) TEM images of single SiO2@Ag (inlet) and distribution of SiO2@Ag in EtOH. (b) UV-visible absorption spectra of nanoparticles (NPs) at each step of the synthesis and that of SiO2@Ag@pr-β-CD added quercetin.
Figure 2
Figure 2
(a) Raman spectra of SiO2@Ag with four flavonoids—quercetin (Que), myricetin (Myr), apigenin (Api), and naringenin (Nar). (b) Raman spectra of SiO2@Ag@pr-β-CD with the four flavonoids.
Figure 3
Figure 3
(a) The Raman intensity of SiO2@Ag-added mixture of apigenin (Api) and quercetin (Que). (b) The Raman intensity of SiO2@Ag@pr-β-CD-added mixture of Api and Que.
Figure 4
Figure 4
(a) Raman spectra of SiO2@Ag@pr-β-CD according to the concentration of Que and (b) its Raman intensity at 636 cm−1.
See this image and copyright information in PMC

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