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. 2019 Oct;38(10):1028-1041.
doi: 10.1016/j.healun.2019.08.002. Epub 2019 Aug 10.

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric heart transplantation report - 2019; Focus theme: Donor and recipient size match

Joseph W Rossano  1 , Tajinder P Singh  1 , Wida S Cherikh  1 , Daniel C Chambers  1 , Michael O Harhay  1 , Don Hayes Jr  1 , Eileen Hsich  1 , Kiran K Khush  1 , Bruno Meiser  1 , Luciano Potena  1 , Alice E Toll  1 , Aparna Sadavarte  1 , Andreas Zuckermann  1 , Josef Stehlik  2 ; International Society for Heart and Lung Transplantation  1
Affiliations

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric heart transplantation report - 2019; Focus theme: Donor and recipient size match

Joseph W Rossano et al. J Heart Lung Transplant. 2019 Oct.
No abstract available

Keywords: children; heart transplant; outcomes; registry; survival.

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Figures

Figure 1
Figure 1
Number of centers reporting pediatric heart transplants.
Figure 2
Figure 2
Number of centers by center volume (transplants: January 2005−June 2018).
Figure 3
Figure 3
Diagnosis distribution by location (transplants: January 2005–June 2018). CHD, congenital heart disease; DCM, dilated cardiomyopathy.
Figure 4
Figure 4
Percentage of patients bridged with mechanical circulatory support by age group and diagnosis (transplants: January 2010–June 2018). CHD, congenital heart disease; DCM, dilated cardiomyopathy; ECMO, extracorporeal membrane oxygenation; TAH, total artificial heart; VAD, ventricular assist device.
Figure 5
Figure 5
PRA distribution by age group and diagnosis (transplants: January 2010–June 2018). CHD, congenital heart disease; DCM, dilated cardiomyopathy; PRA, panel reactive antibody.
Figure 6
Figure 6
Kaplan-Meier survival by recipient age at transplant (transplants: January 1992–June 2017). NS, not significant.
Figure 7
Figure 7
Kaplan-Meier survival conditional to survival to 1 year after transplant, by recipient age at transplant (transplants: January 1992–June 2017). NA, not applicable.
Figure 8
Figure 8
Kaplan-Meier survival by era (transplants: January 1982–June 2017). NA, not applicable.
Figure 9
Figure 9
Kaplan-Meier survival by recipient age group and diagnosis (transplants: January 2005–June 2017). CHD, congenital heart disease; DCM, dilated cardiomyopathy.
Figure 10
Figure 10
Induction immunosuppression use by era (transplants: January 2005–June 2018). ALG, anti-lymphocyte globulin; ATG, anti-thymocyte globulin; IL-2R, interleukin-2 receptor.
Figure 11
Figure 11
Maintenance immunosuppression drug combinations at 1-year follow-up (follow-ups: January 2005–June 2018). AZA, azathioprine; MMF, mycophenolate mofetil; MPA, mycophenolic acid.
Figure 12
Figure 12
Percentage of recipients experiencing treated rejection between discharge and 1-year follow-up by use of induction therapy (follow-ups: January 2005–June 2018). NS, not significant.
Figure 13
Figure 13
Freedom from CAV by use of induction therapy (transplants: January 1995–June 2017). CAV, cardiac allograft vasculopathy.
Figure 14
Figure 14
Survival following report of CAV (transplants: January 2005–June 2017). CAV, cardiac allograft vasculopathy.
Figure 15
Figure 15
Freedom from malignancy (transplants: January 1995–June 2017).
Figure 16
Figure 16
Relative incidence of leading causes of death (deaths: January 2005–June 2018). CAV, cardiac allograft vasculopathy; CMV, cytomegalovirus.
Figure 17
Figure 17
Kaplan-Meier survival rates after retransplant by intertransplant interval (transplants: January 1995–June 2017). TX, transplantation.
Figure 18
Figure 18
Donor-recipient height and weight match (transplants: January 2010–June 2018).
Figure 19
Figure 19
Distribution of donor-recipient weight match by recipient age (transplants: January 2010–June 2018).
Figure 20
Figure 20
Distribution of donor-recipient weight match by geographic location (transplants: January 2010–June 2018).
Figure 21
Figure 21
Kaplan-Meier survival within 1 year of transplant by donor-recipient weight match (transplants: January 2006–June 2017). NS, not significant.
Figure 22
Figure 22
Statistically significant categorical risk factors for 1-year mortality (transplants: January 2006–June 2017). CHD, congenital heart disease; CI, confidence interval; DCM, dilated cardiomyopathy; ECMO, extracorporeal membrane oxygenation; F, female; HR, hazard ratio; LCL, lower control limit; M, male; ReTX, retransplantation; UCL, upper control limit; VAD, ventricular assist device.
Figure 23
Figure 23
Hazard ratio of 1-year mortality by donor-recipient weight match (transplants: January 2006–June 2017).
Figure 24
Figure 24
Hazard ratio of 5-year mortality by donor-recipient height match (transplants: January 2003–June 2013).
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References

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    1. Taghavi S, Wilson LM, Brann SH, Gaughan J, Mangi AA. Cardiac transplantation can be safely performed with low donor-to-recipient body weight ratios. J Card Fail 2012;18:688–93. - PubMed
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