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. 2019 Oct;38(10):1042-1055.
doi: 10.1016/j.healun.2019.08.001. Epub 2019 Aug 8.

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match

Daniel C Chambers  1 , Wida S Cherikh  1 , Michael O Harhay  1 , Don Hayes Jr  1 , Eileen Hsich  1 , Kiran K Khush  1 , Bruno Meiser  1 , Luciano Potena  1 , Joseph W Rossano  1 , Alice E Toll  1 , Tajinder P Singh  1 , Aparna Sadavarte  1 , Andreas Zuckermann  1 , Josef Stehlik  2 ; International Society for Heart and Lung Transplantation  1
Affiliations

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match

Daniel C Chambers et al. J Heart Lung Transplant. 2019 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Number of adult lung transplants by year and procedure type (transplants: 1988–2017).
Figure 2
Figure 2
Major indications for adult lung transplantation by year (absolute number; transplants: 1990–2017). A1ATD, alpha-1-antitrypsin deficiency; CF, cystic fibrosis; COPD, chronic obstructive pulmonary disease; IIP, idiopathic interstitial pneumonia; ILD-not IIP, interstitial lung disease-not idiopathic interstitial pneumonia.
Figure 3
Figure 3
Induction immunosuppression for adult lung transplant recipients (transplants: January 2005–December 2017). ALG, antilymphocyte globulin; ATG, anti-thymocyte globulin; IL-2R, interleukin-2 receptor.
Figure 4
Figure 4
Kaplan-Meier survival for adult lung transplant recipients by transplant era (transplants: 1992–June 2017). NA, not applicable.
Figure 5
Figure 5
Statistically significant categorical risk factors for 10-year mortality for adult lung transplant recipients with 95% CIs (transplants: 2000–June 2008, N = 18,673). CF, cystic fibrosis; CI, confidence interval; CMV, cytomegalovirus; COPD, chronic obstructive pulmonary disorder; CTD, connective tissue disease; DCD, donation after circulatory death; F, female; HR, hazard ratio; LAM, lymphangioleiomyomatosis; LCL, lower control limit; M, male; Retx, retransplantation; UCL, upper control limit.
Figure 6
Figure 6
Hazard ratio for 10-year mortality for adult lung transplant recipients by recipient and donor age (transplants: 2000–June 2008, N = 18,673). This model excludes size match. The reference for recipient age is 54 years and for donor age is 36 years.
Figure 7
Figure 7
Distribution of donor-recipient height difference for adult lung transplant recipients by procedure type and recipient diagnosis (transplants: January 2005–June 2018). A1ATD, alpha-1-antitrypsin deficiency; CF, cystic fibrosis; COPD, chronic obstructive pulmonary disease; IIP, idiopathic interstitial pneumonia; ILD-not IIP, interstitial lung disease-not idiopathic interstitial pneumonia.
Figure 8
Figure 8
Kaplan-Meier survival within 1 year for adult lung transplant recipients by donor-recipient weight difference (transplants: January 1995–June 2017).
Figure 9
Figure 9
Kaplan-Meier survival within 5 years for adult lung transplant recipients by donor-recipient weight difference (transplants: January 1995–June 2013).
Figure 10
Figure 10
Kaplan-Meier survival within 1 year for adult lung transplant recipients by donor-recipient height difference (transplants: January 1995–June 2017).
Figure 11
Figure 11
Kaplan-Meier survival within 5 years for adult lung transplant recipients by donor-recipient height difference for (a) A1ATD/COPD, (b) CF, (c) IIP/ILD-not IIP, and (d) other diagnoses (double lung transplants: January 1995–June 2013). A1ATD, alpha-1-antitrypsin deficiency; CF, cystic fibrosis; COPD, chronic obstructive pulmonary disease; IIP, idiopathic interstitial pneumonia; ILD-not IIP, interstitial lung disease-not idiopathic interstitial pneumonia.
Figure 12
Figure 12
Statistically significant categorical risk factors for 5-year mortality for adult lung transplant recipients with 95% CIs (transplants: 2005–June 2013, N = 27,023). This model includes size match. A1ATD, alpha-1-antitrypsin deficiency; CF, cystic fibrosis; CI, confidence interval; CMV, cytomegalovirus; COPD, chronic obstructive pulmonary disease; F, female; HLA, human leukocyte antigen; HR, hazard ratio; IIP, idiopathic interstitial pneumonia; ILD-not IIP, interstitial lung disease-not idiopathic interstitial pneumonia; LCL, lower control limit; M, male; UCL, upper control limit.
Figure 13
Figure 13
Hazard ratio of 5-year mortality for adult lung transplant recipients by donor-recipient weight difference (transplants: 2005–June 2013, N = 27,023). The reference value for weight difference is 5 kg.
Figure 14
Figure 14
Hazard ratio of 5-year mortality for adult lung transplant recipients by donor-recipient height difference (transplants: 2005–June 2013, N = 27,203). The reference value for height difference is 2.4 cm.
Figure 15
Figure 15
Hazard ratio of 5-year mortality for adult lung transplant recipients by donor-recipient height difference and diagnosis interaction (transplants: 2005–June 2013, N = 27,023). A1ATD, alpha-1-antitrypsin deficiency; CF, cystic fibrosis; COPD, chronic obstructive pulmonary disease; IIP, idiopathic interstitial pneumonia; ILD-not IIP, interstitial lung disease-not idiopathic interstitial pneumonia.
Figure 16
Figure 16
Number of adult heart-lung transplants by transplant year.
Figure 17
Figure 17
Kaplan-Meier survival for adult heart-lung transplant recipients by transplant era (transplants: January 1992–June 2017). NA, not applicable.
Figure 18
Figure 18
Kaplan-Meier survival for adult heart-lung transplant recipients by major diagnosis (transplants: January 1992–June 2017). CF, cystic fibrosis; COPD, chronic obstructive pulmonary disease; IIP, idiopathic interstitial pneumonia; IPAH, idiopathic pulmonary arterial hypertension; NS, not significant; PH, pulmonary hypertension.
Figure 19
Figure 19
Kaplan-Meier survival for adult heart-lung transplant recipients within 5 years by donor-recipient height difference (transplants: January 1992–June 2013). NS, not significant.
Figure 20
Figure 20
Kaplan-Meier survival for adult heart-lung transplant recipients within 5 years by donor-recipient weight difference (transplants: January 1992–June 2013).
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References

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