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. 2019 Oct;38(10):1056-1066.
doi: 10.1016/j.healun.2019.08.004. Epub 2019 Aug 10.

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match

Kiran K Khush  1 , Wida S Cherikh  1 , Daniel C Chambers  1 , Michael O Harhay  1 , Don Hayes Jr  1 , Eileen Hsich  1 , Bruno Meiser  1 , Luciano Potena  1 , Amanda Robinson  1 , Joseph W Rossano  1 , Aparna Sadavarte  1 , Tajinder P Singh  1 , Andreas Zuckermann  1 , Josef Stehlik  2 ; International Society for Heart and Lung Transplantation  1
Affiliations

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match

Kiran K Khush et al. J Heart Lung Transplant. 2019 Oct.

Erratum in

  • ERRATUM.
    [No authors listed] [No authors listed] J Heart Lung Transplant. 2020 Jan;39(1):91. doi: 10.1016/j.healun.2019.11.001. J Heart Lung Transplant. 2020. PMID: 31896417 No abstract available.
No abstract available

Keywords: heart transplant; immunosuppression; organ donation; rejection; survival.

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Conflict of interest statement

Disclosure statement

K.K.K. serves as a scientific advisor and speaker for CareDx, Inc; L.P. serves as a speaker for Thermofisher, Sandoz, One Lambda and Novartis, and is an advisory board member for Qiagen and Novartis; J.S. serves as a consultant for Medtronic and Abbott; J.R. serves as a consultant for Bayer, Novartis, Amgen, and CSL Behring, and A.Z. serves on the speakers bureau of Paragonix, Novartis, Mallincrodt, Sanofi-Genzyme, Franz K€ohler Chemie and on the advisory board for Chiesi. M.H., D.H., T.S., B.M., W.C., A.R. and A.S. have no conflicts to disclose.

Figures

Figure 1
Figure 1
Number of heart transplants (adult and pediatric) by year (transplants: 1988–2017) and geographic region.
Figure 2
Figure 2
Recipient age distribution (adult and pediatric) by era.
Figure 3
Figure 3
Percent of patients bridged with mechanical circulatory support by year and device type (adult heart transplants: 2005–2017); ECMO: extracorporeal membrane oxygenation; LVAD: left ventricular assist device; RVAD: right ventricular assist device; TAH: total artificial heart; VAD: ventricular assist device.
Figure 4
Figure 4
Number and percent of multiorgan transplants reported by year and type of transplant (adult heart transplants; 1994–2017).
Figure 5
Figure 5
Kaplan-Meier survival by era (adult heart transplants: January 1982–June 2017). NA, not available.
Figure 6
Figure 6
Kaplan-Meier survival by era, conditional on survival to 1 year after transplant (adult heart transplants: January 1982–June 2017). NA, not available.
Figure 7
Figure 7
Kaplan-Meier survival within 1 year of transplant by diagnosis (adult heart transplants: January 1985–June 2017); CHD: congenital heart disease; ICM: ischemic cardiomyopathy; NICM: non-ischemic cardiomyopathy; VCM: valvular cardiomyopathy.
Figure 8
Figure 8
Kaplan-Meier survival by diagnosis, conditional on survival to 1 year after transplant (adult heart transplants: January 2005–June 2017); CHD: congenital heart disease; ICM: ischemic cardiomyopathy; NICM: non-ischemic cardiomyopathy; VCM: valvular cardiomyopathy.
Figure 9
Figure 9
Kaplan-Meier survival by recipient age group (years) (adult heart transplants: January 2010–June 2017).
Figure 10
Figure 10
Kaplan-Meier survival by donor/recipient sex (adult heart transplants: January 1992–June 2017).
Figure 11
Figure 11
Cumulative incidence of leading causes of death (adult heart transplants: January 2010–June 2017); CAV: cardiac allograft vasculopathy; CMV: cytomegalovirus; PTLD: posttransplant lymphoproliferative disorder.
Figure 12
Figure 12
Percent of recipients experiencing treated rejection between transplant discharge and 1-year follow-up, by transplant era (adult heart transplants: 2004–2016).
Figure 13
Figure 13
Categorical risk factors for 1-year mortality (adult heart transplants: 2012−June 2017). CHD: congenital heart disease; ECMO: extracorporeal membrane oxygenation; HR, hazard ratio; ICM: ischemic cardiomyopathy; LCL, lower confidence limit; LVAD: left ventricular assist device; MCS: mechanical circulatory support; NICM: non-ischemic cardiomyopathy; RCM: restrictive cardiomyopathy; RETX: retransplant; RVAD: right ventricular assist device; TAH: total artificial heart; UCL, upper confidence limit; VAD: ventricular assist device; VCM: valvular cardiomyopathy.
Figure 14
Figure 14
Statistically significant categorical risk factors for 5-year mortality (adult heart transplants: 2008–June 2013). CI, confidence interval; ECMO: extracorporeal membrane oxygenation; HR, hazard ratio; IABP: intra-aortic balloon pump; LCL, lower confidence limit; LVAD: left ventricular assist device; MCS: mechanical circulatory support; NICM: non-ischemic cardiomyopathy; RCM: restrictive cardiomyopathy; RETX: retransplant; RVAD: right ventricular assist device; TAH: total artificial heart; UCL, upper confidence limit; VAD: ventricular assist device.
Figure 15
Figure 15
Distribution of donor-recipient predicted heart mass (PHM) match by donor-recipient weight match (adult heart transplant: January 2010–June 2018).
Figure 16
Figure 16
Donor-recipient predicted heart mass match by donor-recipient height match (adult heart transplant: January 2010–June 2018).
Figure 17
Figure 17
Transplants with donor-recipient predicted heart mass match of <−20% and >20% by transplant year (adult heart transplants: January 1992–December 2017).
Figure 18
Figure 18
Distribution of donor-recipient predicted heart mass match by donor-recipient sex combinations (adult heart transplants: January 2010–June 2018).
Figure 19
Figure 19
Distribution of donor-recipient predicted heart mass match by recipient pulmonary vascular resistance (adult heart transplants: January 2010–June 2018).
Figure 20
Figure 20
Distribution of donor-recipient predicted heart mass match by geographic location (adult heart transplants: January 2010–June 2018).
Figure 21
Figure 21
Kaplan-Meier survival by donor-recipient weight match (adult heart transplants: January 2008–June 2013). NS, not significant.
Figure 22
Figure 22
Kaplan-Meier survival by donor-recipient predicted heart mass match (adult heart transplants: January 2008–June 2013).
Figure 23
Figure 23
Multivariable hazard ratio plot for 1-year mortality by donor-recipient predicted heart mass match compared to no mismatch (adult heart transplants: 2012–June 2017).
Figure 24
Figure 24
Multivariable hazard ratio plot for 5-year mortality, by donor-recipient predicted heart mass match, compared to no mismatch (adult heart transplants: 2008–June 2013).
See this image and copyright information in PMC

References

    1. Blackbourne LH, Tribble CG, Langenburg SE, et al. Successful use of undersized donors for orthotopic heart transplantation—with a caveat. Ann Thorac Surg 1994;57:1472–6. - PubMed
    1. Sethi GK, Lanauze P, Rosado LJ, et al. Clinical significance of weight difference between donor and recipient in heart transplantation. J Thorac Cardiovasc Surg 1993;106:444–8. - PubMed
    1. Taghavi S, Wilson LM, Brann SH, Gaughan J, Mangi AA. Cardiac transplantation can be safely performed with low donor-to-recipient body weight ratios. J Card Fail 2012;18:688–93. - PubMed
    1. Kransdorf EP, Kittleson MM, Benck LR, et al. Predicted heart mass is the optimal metric for size match in heart transplantation. J Heart Lung Transplant 2019;38:156–65. - PubMed
    1. Reed RM, Netzer G, Hunsicker L, et al. Cardiac size and sex-matching in heart transplantation: size matters in matters of sex and the heart. JACC Heart Fail 2014;2:73–83. - PMC - PubMed

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