Cancer Genetic Counseling-Current Practice and Future Challenges
- PMID: 31548230
- PMCID: PMC7263095
- DOI: 10.1101/cshperspect.a036541
Cancer Genetic Counseling-Current Practice and Future Challenges
Abstract
Cancer genetic counseling practice is rapidly evolving, with services being provided in increasingly novel ways. Pretest counseling for cancer patients may be abbreviated from traditional models to cover the elements of informed consent in the broadest of strokes. Genetic testing may be ordered by a cancer genetics professional, oncology provider, or primary care provider. Increasingly, direct-to-consumer testing options are available and utilized by consumers anxious to take control of their genetic health. Finally, genetic information is being used to inform oncology care, from surgical decision-making to selection of chemotherapeutic agent. This review provides an overview of the current and evolving practice of cancer genetic counseling as well as opportunities and challenges for a wide variety of indications in both the adult and pediatric setting.
Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.
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References
-
- Abida W, Cheng ML, Armenia J, Middha S, Autio KA, Vargas HA, Rathkopf D, Morris MJ, Danila DC, Slovin SF, et al. 2019. Analysis of the prevalence of microsatellite instability in prostate cancer and response to immune checkpoint blockade. JAMA Oncol 5: 471–478. 10.1001/jamaoncol.2018.5801 - DOI - PMC - PubMed
-
- Almqvist EW, Brinkman RR, Wiggins S, Hayden MR, Canadian Collaborative Study of Predictive Testing. 2003. Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington's disease. Clin Genet 64: 300–309. 10.1034/j.1399-0004.2003.00157.x - DOI - PubMed
-
- Amendola LM, Jarvik GP, Leo MC, McLaughlin HM, Akkari Y, Amaral MD, Berg JS, Biswas S, Bowling KM, Conlin LK, et al. 2016. Performance of ACMG-AMP variant-interpretation guidelines among nine laboratories in the Clinical Sequencing Exploratory Research Consortium. Am J Hum Genet 99: 247 10.1016/j.ajhg.2016.06.001 - DOI - PMC - PubMed
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