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. 2019 Nov;31(46):e1904535.
doi: 10.1002/adma.201904535. Epub 2019 Sep 24.

Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

Huimin Li  1 , Huilin Guo  1   2 , Chang Lei  3 , Li Liu  1 , Liqin Xu  1 , Yaping Feng  1 , Jin Ke  1   2 , Wei Fang  1   2 , Hao Song  3 , Chun Xu  4 , Chengzhong Yu  3 , Xing Long  1   2
Affiliations

Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

Huimin Li et al. Adv Mater. 2019 Nov.

Abstract

Osteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi-injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and generate endogenous HA with high molecular weights. In a rat TMJ osteoarthritis inflammation model, this strategy promotes endogenous HA production and inhibits the synovial inflammation of OA for more than 3 weeks with one-shot administration. Such nanotherapy also helps repairing the bone defects in a rat OA bone defect model.

Keywords: drug carriers; hyaluronic acid; nanoparticles; osteoarthritis; protein delivery.

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