Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Sep 24;14(9):e0222815.
doi: 10.1371/journal.pone.0222815. eCollection 2019.

Serum E-selectin concentration is associated with risk of metabolic syndrome in females

Chien-Hsing Lee  1 , Feng-Chih Kuo  1 , Wen-Hao Tang  2 , Chieh-Hua Lu  1 , Sheng-Chiang Su  1 , Jhih-Syuan Liu  1 , Chang-Hsun Hsieh  1 , Yi-Jen Hung  2 , Fu-Huang Lin  3
Affiliations

Serum E-selectin concentration is associated with risk of metabolic syndrome in females

Chien-Hsing Lee et al. PLoS One. .

Abstract

Objectives: Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and MetS were further evaluated.

Methods: A total of 205 patients were recruited from the outpatient clinics of Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria were age between 20-75 years and BMI < 35 kg/m2. Demographic, anthropometric and MetS index data were compared between genders. Markers of inflammation and endothelial dysfunction were compared between individuals with or without MetS by gender.

Results: Age-adjusted E-selectin values showed significant positive correlations with BMI, waist-hip ratio, fasting plasma glucose, systolic and diastolic blood pressure, triglycerides, TNF-α, hsCRP and ICAM-1, and inverse correlation with HDL cholesterol. E-selectin levels were positively correlated with numbers of MetS components in females (P < 0.001) but not in males (P = 0.125).

Conclusions: Increased E-selectin levels are significantly associated with increased MetS risk in females, but not in males.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The level of plasma E-selectin concentration across different numbers of MS components (0 to 5 components) by gender.
The circles represent individual values of each patient, and the lines represent median values in each category.
Fig 2
Fig 2. ROC curve analysis of values for inflammatory markers (TNF-α, IL-6, hsCRP) and endothelial dysfunction markers (E-selectin, ICAM-1, VCAM-1) in the detection of MetS status, as shown by gender.
See this image and copyright information in PMC

References

    1. Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, et al. Adiponectin as a biomarker of the metabolic syndrome. Circulation Journal. 2004; 68(11):975–81. 10.1253/circj.68.975 - DOI - PubMed
    1. Gündogan K, Bayram F, Capak M, Tanriverdi F, Karaman A, Ozturk A, et al. Prevalence of metabolic syndrome in the Mediterranean region of Turkey: evaluation of hypertension, diabetes mellitus, obesity, and dyslipidemia. Metabolic Syndrome and Related Disorders. 2009; 7(5):427–34. 10.1089/met.2008.0068 - DOI - PubMed
    1. Iqbal Hydrie MZ, Shera AS, Fawwad A, Basit A, Hussain D Sc A. Prevalence of metabolic syndrome in urban Pakistan (Karachi): comparison of newly proposed International Diabetes Federation and modified Adult Treatment Panel III criteria. Metabolic Syndrome and Related Disorders. 2009; 7(2):119–24. 10.1089/met.2008.0055 - DOI - PubMed
    1. Pan W-H, Yeh W-T, Weng L-C. Epidemiology of metabolic syndrome in Asia. Asia Pacific Journal of Clinical Nutrition. 2008; 17(S1):37–42. - PubMed
    1. Misra A, Khurana L. The metabolic syndrome in South Asians: epidemiology, determinants, and prevention. Metabolic Syndrome and Related Disorders. 2009; 7(6):497–514. 10.1089/met.2009.0024 - DOI - PubMed

Publication types