Transposition: A CRISPR Way to Get Around
- PMID: 31550477
- DOI: 10.1016/j.cub.2019.08.010
Transposition: A CRISPR Way to Get Around
Abstract
CRISPR-Cas systems provide sequence-specific immunity against selfish genetic elements in prokaryotes. Now, two studies show that transposon-encoded variants can guide sequence-specific transposition. These findings have important practical implications but also raise questions of why and how this strategy would benefit transposons.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Comment on
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RNA-guided DNA insertion with CRISPR-associated transposases.Science. 2019 Jul 5;365(6448):48-53. doi: 10.1126/science.aax9181. Epub 2019 Jun 6. Science. 2019. PMID: 31171706 Free PMC article.
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Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration.Nature. 2019 Jul;571(7764):219-225. doi: 10.1038/s41586-019-1323-z. Epub 2019 Jun 12. Nature. 2019. PMID: 31189177
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