Cohort profile: the clinical 'Psoriasis in Adolescents' (PIA) cohort in Denmark
- PMID: 31551390
- PMCID: PMC6773347
- DOI: 10.1136/bmjopen-2019-031448
Cohort profile: the clinical 'Psoriasis in Adolescents' (PIA) cohort in Denmark
Abstract
Purpose: Psoriasis is a chronic inflammatory skin disease that frequently debuts in childhood and adolescence. We wished to determine environmental and genetic risk factors for the development of psoriasis in children and adolescents, as well as to investigate debut type, trigger factors, course of disease, nature and influence of stress related to both child and family and risk factors for comorbidity. The 'Psoriasis in Adolescents' (PIA) cohort will provide data on the relationship between psoriasis and, respectively, genetic disposition, early-life exposures, quality of life and comorbidity.
Participants: The PIA cohort is nested in the large general population Danish National Birth Cohort (DNBC). We invited 390 adolescents with psoriasis and corresponding maternally predisposed and non-predisposed controls. Participants underwent an interview and a clinical examination consisting of a skin inspection and physical measurements including blood sampling and microbiological swabs. Additionally, four self-administered questionnaires on physical and mental health were completed.
Findings to date: The final PIA cohort consists of 81 adolescents with psoriasis, 110 parentally predisposed and 124 non-predisposed psoriasis-free adolescents. The validity of the maternally reported psoriasis status from the DNBC was found to be low on clinical examination (47.5%). In contrast, the self-reported psoriasis status of the DNBC mothers was clinically confirmed in 80.8% of the cases.
Future plans: The PIA cohort offers the possibility of assessing the clinical characteristics, course of psoriasis and development of comorbidities in adolescents with clinically confirmed disease from a general population. Comparison with predisposed and non-predisposed controls is possible and genetic analyses are scheduled. We plan to invite the participants for a follow-up in 5-10 years. Furthermore, we plan to include newly diagnosed adolescents with psoriasis from the 18-year DNBC follow-up. All information is linkable on the individual level with data from the DNBC and nationwide registries in Denmark.
Keywords: cardiovascular; comorbidity; genetics; metabolic; paediatric dermatology; psoriasis.
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Conflict of interest statement
Competing interests: None declared.
Figures
Similar articles
-
Clinical characteristics including cardiovascular and metabolic risk factors in adolescents with psoriasis.J Eur Acad Dermatol Venereol. 2020 Jul;34(7):1516-1523. doi: 10.1111/jdv.16229. Epub 2020 Feb 19. J Eur Acad Dermatol Venereol. 2020. PMID: 31989688
-
Psoriasis and mental health in adolescents: A cross-sectional study within the Danish National Birth Cohort.J Affect Disord. 2024 Aug 1;358:318-325. doi: 10.1016/j.jad.2024.05.009. Epub 2024 May 3. J Affect Disord. 2024. PMID: 38703911
-
Mother's dietary quality during pregnancy and offspring's dietary quality in adolescence: Follow-up from a national birth cohort study of 19,582 mother-offspring pairs.PLoS Med. 2019 Sep 12;16(9):e1002911. doi: 10.1371/journal.pmed.1002911. eCollection 2019 Sep. PLoS Med. 2019. PMID: 31513597 Free PMC article.
-
Early environmental risk factors and coeliac disease in adolescents: a population-based cohort study in Denmark.BMJ Open. 2023 Nov 27;13(11):e061006. doi: 10.1136/bmjopen-2022-061006. BMJ Open. 2023. PMID: 38011980 Free PMC article. Review.
-
Risk Factors for the Development of Psoriasis.Int J Mol Sci. 2019 Sep 5;20(18):4347. doi: 10.3390/ijms20184347. Int J Mol Sci. 2019. PMID: 31491865 Free PMC article. Review.
Cited by
-
The Risk of Systemic Diseases in Those with Psoriasis and Psoriatic Arthritis: From Mechanisms to Clinic.Int J Mol Sci. 2020 Sep 24;21(19):7041. doi: 10.3390/ijms21197041. Int J Mol Sci. 2020. PMID: 32987907 Free PMC article. Review.
-
The Current Advancement in Psoriasis.Cureus. 2023 Oct 13;15(10):e47006. doi: 10.7759/cureus.47006. eCollection 2023 Oct. Cureus. 2023. PMID: 37965393 Free PMC article. Review.
-
Exploring comorbidity and pharmacological treatment patterns in psoriasis - a retrospective population-based cross-sectional study.J Multimorb Comorb. 2023 Oct 30;13:26335565231212336. doi: 10.1177/26335565231212336. eCollection 2023 Jan-Dec. J Multimorb Comorb. 2023. PMID: 37915465 Free PMC article.
-
Development and preliminary validation of the Adolescent Psoriasis Quality of Life instrument: a disease-specific measure of quality of life in adolescents with psoriasis.Br J Dermatol. 2020 Jul;183(1):96-104. doi: 10.1111/bjd.18719. Epub 2020 Jan 29. Br J Dermatol. 2020. PMID: 31743420 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical