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. 2020 Feb;15(2):263-264.
doi: 10.4103/1673-5374.265551.

Ependymal cells and multiple sclerosis: proposing a relationship

Dale Hatrock  1 , Nina Caporicci-Dinucci  1 , Jo Anne Stratton  2
Affiliations

Ependymal cells and multiple sclerosis: proposing a relationship

Dale Hatrock et al. Neural Regen Res. 2020 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

None

Figures

Figure 1
Figure 1
Proposed mechanisms of molecular interactions between CSF-associated factors and ependymal cells in MS. Cytokines, such as INFγ and Cxcl12, as well as myelin debris circulate in the CSF of MS patients. Ependymal cells are equipped with receptors that have binding affinity for INFγ and Cxcl12, and have also been shown to be sensitive to myelin-induced damage. In addition, T-helper cells in MS likely interact directly with ependymal cells via Fas-FasL binding, and may contribute to ependymal cell dysfunction or death. Created with BioRender.com. CSF: Cerebrospinal fluid; INF: interferon; MS: multiple sclerosis.
See this image and copyright information in PMC

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