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. 2019 Oct 25;82(10):2828-2834.
doi: 10.1021/acs.jnatprod.9b00522. Epub 2019 Sep 25.

Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon

Yuen P Tan, Yongbo Xue  1 , Andrei I Savchenko, Sevan D Houston, Naphak Modhiran, Christopher L D McMillan, Glen M Boyle  2 , Paul V Bernhardt, Paul R Young, Daniel Watterson, Craig M Williams
Affiliations

Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon

Yuen P Tan et al. J Nat Prod. .

Abstract

The highly oxygenated pimarane diterpenoids basimarols A, B, and C (3-5) were isolated from the plant species Basilicum polystachyon, which was collected within the Australian arid zone. Structure elucidation was performed using a suite of spectroscopic techniques, including X-ray crystallography. Anticancer and anti-DENV activity of 3-5 was explored, but only limited activity was observed. More extensive antiviral evaluation of stachyonic acid A (1), which was also isolated from B. polystachyon, revealed broad spectrum antiviral activity against West Nile virus (Kunjin strain, WNVKun) and human influenza viruses H1N1 and H3N2.

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