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Review
. 2019 Oct;39(10):e210-e218.
doi: 10.1161/ATVBAHA.119.312413. Epub 2019 Sep 25.

Protease Activity in Vascular Disease

Megan A Slack  1 , Scott M Gordon  1
Affiliations
Review

Protease Activity in Vascular Disease

Megan A Slack et al. Arterioscler Thromb Vasc Biol. 2019 Oct.
No abstract available

Keywords: aneurysm; atherosclerosis; cytokines; extracellular matrix; inflammation.

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Figures

Figure 1.
Figure 1.. Expression of proteases and protease activated receptors in the vasculature.
Inflammation in the vasculature results in the generation of proteases by both stromal and inflammatory cells. Protease activity can contribute to vascular pathogenesis by propagating inflammation and causing structural damage, increasing risk of an atherothrombotic event. Protease-activated receptors (PARs) sense protease activity and drive cellular responses. These responses are typically proinflammatory and are dependent on the specific PARs that are expressed and the cell type. This figure emphasizes the distribution of proteases and PARs examined in recent literature. NE – neutrophil elastase; PR3 – proteinase 3; Cat-G – cathepsin G; uPA – urokinase-type plasminogen activator; MMP – matrix metalloproteinase.
See this image and copyright information in PMC

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Publication types