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Editorial
. 2019 Oct;39(10):1899-1901.
doi: 10.1161/ATVBAHA.119.313279. Epub 2019 Sep 25.

Unfolding the Story of Proteoglycan Accumulation in Thoracic Aortic Aneurysm and Dissection

Ying H Shen  1   2 , Hong S Lu  3   4 , Scott A LeMaire  1   2 , Alan Daugherty  3   4
Affiliations
Editorial

Unfolding the Story of Proteoglycan Accumulation in Thoracic Aortic Aneurysm and Dissection

Ying H Shen et al. Arterioscler Thromb Vasc Biol. 2019 Oct.
No abstract available

Keywords: ADAMTS proteases; Editorial; aggrecans; aortic aneurysm; aortic dissection; extracellular matrix; proteoglycans.

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Conflict of interest statement

Disclosures

The authors have no potential conflicts of interest to disclose.

Figures

Figure.
Figure.. Proteoglycan metabolism in aortic wall.
A, Illustration of normal aortic wall with intact proteoglycans (PG), such as aggrecans, attached to hyaluronan (HA) and healthy smooth muscle cells (SMC). B, Illustration of degenerative aortic wall with accumulated proteoglycan (eg, aggrecan) fragments, elastic fiber fragmentation, and SMC death. C, Schematic structure of an aggrecan core protein that contains globular domains (G1, G2, and G3) and an interglobular domain (IGD). Glycosaminoglycan keratan sulfate (KS) and chondroitin sulfate (CS1 and CS2) chains are attached to the core protein. The location of cleavage sites along the core protein is indicated.
See this image and copyright information in PMC

Comment on

References

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