Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis Attributable to Steatohepatitis?

Morten A Karsdal¹, Sönke Detlefsen², Samuel J Daniels^{1

3}, Mette J Nielsen¹, Aleksander Krag^{3

4}, Detlef Schuppan^{5

6}

Affiliations

¹ Nordic Bioscience Biomarkers and Research A/S, Herlev, Denmark.
² Department of Pathology, Odense University Hospital, Odense, Denmark.
³ Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
⁴ Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark.
⁵ Institute of Translational Immunology and Research Center for Immunotherapy, University of Mainz Medical Center, Mainz, Germany.
⁶ Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Review

Morten A Karsdal et al. Hepatology. 2020 Jan.

. 2020 Jan;71(1):346-351.

doi: 10.1002/hep.30969. Epub 2019 Dec 18.

Morten A Karsdal¹, Sönke Detlefsen², Samuel J Daniels^{1

3}, Mette J Nielsen¹, Aleksander Krag^{3

4}, Detlef Schuppan^{5

6}

¹ Nordic Bioscience Biomarkers and Research A/S, Herlev, Denmark.
² Department of Pathology, Odense University Hospital, Odense, Denmark.
³ Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
⁴ Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark.
⁵ Institute of Translational Immunology and Research Center for Immunotherapy, University of Mainz Medical Center, Mainz, Germany.
⁶ Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

No abstract available

References

1. Segnani C, Ippolito C, Antonioli L, Pellegrini C, Blandizzi C, Dolfi A, et al. Histochemical detection of collagen fibers by Sirius Red/Fast Green is more sensitive than van Gieson or Sirius Red alone in normal and inflamed rat colon. PLoS One 2015;10:e0144630.
1. Karsdal MA, Nielsen SH, Leeming DJ, Langholm LL, Nielsen MJ, Manon-Jensen T, et al. The good and the bad collagens of fibrosis-their role in signaling and organ function. Adv Drug Deliv Rev 2017;121:43-56.
1. Karsdal MA, Manon-Jensen T, Genovese F, Kristensen JH, Nielsen MJ, Sand JMB, et al. Novel insights into the function and dynamics of extracellular matrix in liver fibrosis. Am J Physiol Liver Physiol 2015;308:G807-G830.
1. Schuppan D, Ruehl M, Somasundaram R, Hahn EG. Matrix as a modulator of hepatic fibrogenesis. Semin Liver Dis 2001;21:351-372.
1. Sand JMB, Genovese F, Karsdal MA. Chapter 4. Type IV collagen. In: Karsdal MA, ed. Biochemistry of Collagens, Laminins and Elastin. New York, NY: Academic; 2016.