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. 2019 Oct;18(4):2972-2978.
doi: 10.3892/etm.2019.7890. Epub 2019 Aug 14.

Prognostic value of fibrinogen-to-albumin ratio in predicting 1-year clinical progression in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention

Dongxu He  1 , Yundi Jiao  1 , Tongtong Yu  1 , Jia Song  1 , Zongyu Wen  1 , Jiake Wu  1 , Weili Duan  1 , Na Sun  1 , Zhijun Sun  1 , Zhaoqing Sun  1
Affiliations

Prognostic value of fibrinogen-to-albumin ratio in predicting 1-year clinical progression in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention

Dongxu He et al. Exp Ther Med. 2019 Oct.

Abstract

Previous studies have indicated that fibrinogen and low serum albumin levels are associated with poor cardiovascular outcomes. The objective of the present study was to examine whether the fibrinogen-to-albumin ratio (FAR) was able to predict the 1-year prognosis of patients with non-ST elevation acute coronary syndrome (NSTE-ACS) following percutaneous coronary intervention (PCI). A total of 1,352 patients with NSTE-ACS undergoing PCI were included in this prospective study and were divided into a low-FAR group (FAR ≤8.713, n=901) and a high-FAR group (FAR>8.713, n=451). FAR was defined as the concentration ratio of fibrinogen (mg/dl) to albumin (mg/dl) multiplied by 100. The endpoint was the incidence of major adverse cardiovascular events (MACEs), including all-cause mortality, cardiac mortality, non-fatal myocardial reinfarction and unscheduled repeat revascularisation. The predictive performance was validated by receiver-operator characteristic (ROC) curve analysis. A total of 127 MACEs were noted during the 1-year follow-up period. Multivariate Cox analysis suggested that a high FAR was an independent predictor of all-cause mortality (hazard ratio=2.223, 95% confidence interval: 1.002-4.931, P=0.049). Regarding the predictor of MACEs, the FAR exhibited an area under the ROC curve of 0.676 with a sensitivity of 0.630 and a specificity of 0.726. The cut-off value was 9.114. The FAR was an independent prognostic factor in NSTE-ACS. The present results suggest that the FAR may serve as a potential prognostic indicator for patients with NSTE-ACS undergoing PCI (approval no. NCT02667548; January 29, 2016; Shengjing Hospital of China Medical University).

Keywords: fibrinogen-to-albumin ratio; major adverse cardiovascular events; non-ST elevation acute coronary syndrome; percutaneous coronary intervention.

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Figures

Figure 1.
Figure 1.
Flow diagram of participant selection. FAR, fibrinogen-to-albumin ratio; PCI, percutaneous coronary intervention; NSTE-ACS, non-ST elevation acute coronary syndrome.
Figure 2.
Figure 2.
Kaplan-Meier survival curves of all-cause mortality based on FAR levels. FAR, fibrinogen-to-albumin ratio.
Figure 3.
Figure 3.
Kaplan-Meier survival curves for cardiac mortality based on FAR levels. FAR, fibrinogen-to-albumin ratio.
Figure 4.
Figure 4.
ROC curve indicating the predictive value of FAR. ROC, receiver operating characteristic; AUC, area under ROC curve; FAR, fibrinogen-to-albumin ratio.
See this image and copyright information in PMC

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