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Review
. 2020 May;20(5):403-412.
doi: 10.1002/tcr.201900053. Epub 2019 Sep 26.

Hybrid Reaction Systems for the Synthesis of Alkylated Compounds Based upon Cu-Catalyzed Coupling of Radicals and Organometallic Species

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Review

Hybrid Reaction Systems for the Synthesis of Alkylated Compounds Based upon Cu-Catalyzed Coupling of Radicals and Organometallic Species

Kentaro Takeuchi et al. Chem Rec. 2020 May.

Abstract

A transition metal catalyzed alkylation with an alkyl halide is one of the most difficult reactions to achieve, because of the difficult oxidative addition of an alkyl-halogen bond to a metal, and the tendency of the resulting alkylmetal intermediate to undergo a β-hydride elimination reaction to give an olefin. In this review, we discuss hybrid reaction systems involving Cu catalyzed combination of radicals and organometallic species, which enable facile alkylation reactions to construct C-C and C-heteroatom bonds. This paper highlights recent progress in arylation, alkenylation, alkynylation, cyclization, addition and introduction of heteroatoms via these hybrid reaction systems.

Keywords: addition; alkylation; copper; coupling; radical.

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References

    1. None
    1. P. I. Dalko, Tetrahedron 1995, 51, 7579-7876;
    1. I. Ryu, Chem. Rec. 2002, 2, 249-258;
    1. E. Godineau, Y. Landais, Chem. Eur. J. 2009, 15, 3044-3055.
    1. F. Wang, P. Chen, G. Liu, Acc. Chem. Res. 2018, 51, 2036-2046.

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