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Review
. 2019 Sep 25;55(10):638.
doi: 10.3390/medicina55100638.

Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature

Alessandro Allegra  1 , Giovanna Spatari  2 , Stefano Mattioli  3 , Stefania Curti  4 , Vanessa Innao  5 , Roberta Ettari  6 , Andrea Gaetano Allegra  7 , Concetto Giorgianni  8 , Sebastiano Gangemi  9 , Caterina Musolino  10
Affiliations
Review

Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature

Alessandro Allegra et al. Medicina (Kaunas). .

Abstract

Background and objective: The aim of the present study was to evaluate associations between cumulative and peak formaldehyde exposure and occurrence of acute myeloid leukemia. Material and Methods: A comprehensive search was performed using the PubMed and Embase databases. We included studies presenting information about the role of formaldehyde in leukemic occurrence and mortality risk. Then, full texts of the selected references were assessed, and references of included studies were checked to identify additional articles. Result: The information was then summarized and organized in the present review. A total of 81 articles were obtained from the search. Conclusion: Findings from the review of the literature do not support the hypothesis that formaldehyde is a cause of acute myeloid leukemia.

Keywords: acute myeloid leukemia; cancer; carcinogenesis; formaldehyde; occupational exposure.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Possible formaldehyde (FA) genotoxic and cytotoxic actions.
See this image and copyright information in PMC

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