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Review
. 2016 Jan 15;5(1):3.
doi: 10.3390/antib5010003.

Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation

Vijaya Knight  1   2 , Patricia A Merkel  3 , Michael D O'Sullivan  4   5
Affiliations
Review

Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation

Vijaya Knight et al. Antibodies (Basel). .

Abstract

The association of autoantibodies to cytokines with immune deficiency, autoimmunity and/or immune dysregulation is increasingly being recognized. For example, autoantibodies to interferon gamma have been found to be associated with chronic, treatment refractory infections with intracellular organisms such as mycobacteria, autoantibodies to interleukin 17 with chronic mucocutaneous candidiasis, and anti-interferon alpha autoantibodies with systemic lupus erythematosus. While low titer autoantibodies to these and other cytokines may be detected in normal individuals, patients with infectious or autoimmune manifestations tend to have high titer autoantibodies that may block or potentiate the function of the respective cytokine. Recognition of these autoantibodies is important because it may direct treatment toward a combination of adjunctive immunotherapy to modulate the autoantibody level while continuing with appropriate anti-microbial therapy. This review focuses on the anti-cytokine autoantibodies documented to date, their autoimmune, immune dysregulation and infectious disease associations, methods for detection of these antibodies and potential treatment options.

Keywords: ARDS; SLE; autoantibodies; chronic mucocutaneous candidiasis; cytokines; immune deficiency; immune dysregulation; interleukin; non-tuberculous mycobacteria; rheumatoid arthritis.

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Figures

Figure 1
Figure 1
Anticytokine AAbs and disease associations.
See this image and copyright information in PMC

References

    1. Browne S.K. Anticytokine autoantibody-associated immunodeficiency. Ann. Rev. Immunol. 2014;32:635–657. doi: 10.1146/annurev-immunol-032713-120222. - DOI - PubMed
    1. Browne S.K., Holland S.M. Anticytokine autoantibodies in infectious diseases: Pathogenesis and mechanisms. Lancet Infect. Dis. 2010;10:875–885. doi: 10.1016/S1473-3099(10)70196-1. - DOI - PubMed
    1. Browne S.K., Holland S.M. Immunodeficiency secondary to anticytokine autoantibodies. Curr. Opin. Allergy Clin. Immunol. 2010;10:534–541. doi: 10.1097/ACI.0b013e3283402b41. - DOI - PMC - PubMed
    1. Boehm U., Klamp T., Groot M., Howard J.C. Cellular responses to interferon-gamma. Ann. Rev. Immunol. 1997;15:749–795. doi: 10.1146/annurev.immunol.15.1.749. - DOI - PubMed
    1. Shibata Y., Berclaz P.Y., Chroneos Z.C., Yoshida M., Whitsett J.A., Trapnell B.C. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity. 2001;15:557–567. doi: 10.1016/S1074-7613(01)00218-7. - DOI - PubMed

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