Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct;47(10):4625-4635.
doi: 10.1177/0300060519872899. Epub 2019 Sep 26.

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

Qi Zhang  1 , Zhuxiao Ren  2 , Jie Yang  2 , Aihua Yin  1
Affiliations

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

Qi Zhang et al. J Int Med Res. 2019 Oct.

Abstract

Congenital leukemia (CL), defined as manifestations of leukemia within the first 4 weeks of life, is a rare condition with an estimated incidence of only 1 to 5 per million live births. Despite extensive research and the clinical application of new therapies, the prognosis of CL remains poor. Few large-scale studies have investigated the factors affecting the outcomes of infants with CL. Here, we conducted a retrospective study and analysis of CL cases published in the English language from 1 January 2001 to 1 May 2016. Our goal was to provide updated information about this rare disease and to investigate factors that may affect the outcomes of patients with CL.

Keywords: Congenital leukemia; KMT2A translocation; chemotherapy; neonate; prognosis; spontaneous remission.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Two-year overall survival rate of patients with congenital leukemia. The 2-year overall survival rate among all 59 patients was 44.2% and the median lifespan was 210 days. pOS, overall survival percent.
Figure 2.
Figure 2.
Two-year overall survival rates of patients with congenital leukemia with and without chemotherapy. There was no significant difference in 2-year overall survival rates between 34 patients with chemotherapy and 25 patients without chemotherapy. pOS, overall survival percent.
Figure 3.
Figure 3.
Two-year overall survival rates of patients with congenital leukemia with and without KMT2A translocations. The 2-year overall survival rate was significantly higher in the 29 patients without KMT2A translocations compared with the 22 patients with translocations (P = 0.001). pOS, overall survival percent.
See this image and copyright information in PMC

References

    1. Orbach D, Sarnacki S, Brisse HJ, et al. Neonatal cancer. Lancet Oncol 2013; 14: e609–e620. - PubMed
    1. Sande JE, Arceci RJ, Lampkin BC. Congenital and neonatal leukemia. Semin Perinatol 1999; 23: 274–285. - PubMed
    1. van der Linden MH, Creemers S, Pieters R. Diagnosis and management of neonatal leukaemia. Semin Fetal Neonatal Med 2012; 17: 192–195. - PubMed
    1. Amador-Ortiz C, Hurley MY, Ghahramani GK, et al. Use of classic and novel immunohistochemical markers in the diagnosis of cutaneous myeloid sarcoma. J Cutan Pathol 2011; 38: 945–953. - PubMed
    1. Vora A. Childhood leukaemia: an update. Paediatr Child Health 2015: 26: 2.

Substances