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Comment
. 2019 Sep 26;134(13):995-996.
doi: 10.1182/blood.2019002592.

A rose is a rose is a rose, or not

Affiliations
Comment

A rose is a rose is a rose, or not

Steven L Spitalnik. Blood. .

Abstract

In this issue of Blood, Roubinian et al provide important evidence to confirm, and refute, a long-standing maxim in clinical medicine that a 1-unit transfusion of red blood cells (RBCs) should yield a posttransfusion hemoglobin increment of 1 g/dL. Although true, in general, this rule was not always accurate, and deviations could be misleading. They evaluated many single-unit transfusion outcomes in stable adult patients by mining electronic health records (EHRs) and linked blood donor data. This approach was not only pragmatic, but it also points the way to future studies.

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Conflict of interest statement

Conflict-of-interest disclosure: S.L.S. is a member of the Scientific Advisory Board of Hemanext, Inc.

Comment on

References

    1. Roubinian NH, Plimier C, Woo JP, et al. . Effect of donor, component, and recipient characteristics on hemoglobin increments following red blood cell transfusion. Blood. 2019;134(13):1003-1013. - PMC - PubMed
    1. Spitalnik SL, Triulzi D, Devine DV, et al. ; State of the Science in Transfusion Medicine Working Groups . 2015 proceedings of the National Heart, Lung, and Blood Institute’s State of the Science in Transfusion Medicine symposium. Transfusion. 2015;55(9):2282-2290. - PMC - PubMed
    1. Cure P, Bembea M, Chou S, et al. . 2016 proceedings of the National Heart, Lung, and Blood Institute’s scientific priorities in pediatric transfusion medicine. Transfusion. 2017;57(6):1568-1581. - PMC - PubMed
    1. National Heart, Lung, and Blood Institute Towards Minimally-invasive or Non-invasive Approaches to Assess Tissue Oxygenation Pre- and Post-Transfusion Workshop 2018 - Executive Summary. Available at: https://www.nhlbi.nih.gov/events/2018/tissue-oxygenation-workshop. Accessed 30 July 2019.
    1. National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS) Program. Available at: https://www.nhlbi.nih.gov/science/recipient-epidemiology-and-donor-evalu.... Accessed 30 July 2019. - PMC - PubMed