Concanavalin-A-activated lymphocytes suppress immune responses in vitro but are helper cells in vivo
- PMID: 3155873
- DOI: 10.1111/j.1365-3083.1985.tb01399.x
Concanavalin-A-activated lymphocytes suppress immune responses in vitro but are helper cells in vivo
Abstract
In vitro concanavalin A (Con A)-activated spleen cells suppressed the primary in vitro immune response of syngeneic spleen cells to sheep erythrocytes (SRBC) but enhanced the in vivo anti-SRBC responses when transferred to syngeneic untreated mice. Con-A-activated spleen cells injected into nude mice enabled these mice to respond to SRBC.
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