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Meta-Analysis
. 2019 Sep 26;55(10):645.
doi: 10.3390/medicina55100645.

Helicobacter pylori Infection and Psoriasis: A Systematic Review and Meta-Analysis

Mingyang Yu  1 , Rongguang Zhang  2 , Peng Ni  3 , Shuaiyin Chen  4 , Guangcai Duan  5
Affiliations
Meta-Analysis

Helicobacter pylori Infection and Psoriasis: A Systematic Review and Meta-Analysis

Mingyang Yu et al. Medicina (Kaunas). .

Abstract

Background and Objectives: To perform a systematic review and meta-analysis with the aim of determining the relationship between H. pylori infection and psoriasis. Methods: Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Web of Science were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses. Results: The initial database search resulted in 204 articles. Through exclusion and screening, 11 studies involving a total of 1741 participants were finally included in this meta-analysis. The odds ratio (OR) of H. pylori infection rate in the psoriasis group was significantly higher than that in the control group (OR = 1.19, 95% CI 1.15-2.52, P = 0.008). Subgroup analysis showed that no significant difference was detected between the Asia group and the Europe group. As for the methods of H. pylori detection, a statistically significant increase of H. pylori infection in the IgG ELISA test group was detected, compared with the urea breath test group. In addition, analysis based on the severity of psoriasis showed a statistically significant increase of H. pylori infection in moderate and severe psoriasis patients (OR = 2.27; 95% CI: 1.42-3.63, I2 = 27%), but not in the mild psoriasis patients (OR = 1.10; 95% CI: 0.79-1.54, I2 = 0%). Conclusion: H. pylori infection is associated with psoriasis, and psoriasis patients with H. pylori infection have higher Psoriasis Area and Severity Index (PASI) scores. The findings are of considerable significance for the clinical practices.

Keywords: Helicobacter pylori; infection; psoriasis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the study selection.
Figure 2
Figure 2
H. pylori infection in patients with or without psoriasis.
Figure 3
Figure 3
Sub-analysis according to region.
Figure 4
Figure 4
Sub-analysis according to the H. pylori detection methods.
Figure 5
Figure 5
Sub-analysis according to the severity of psoriasis.
See this image and copyright information in PMC

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