Utilization of Chimeric Antigen Receptor T-cell Therapy in Adults

Abstract

Objective: To discuss the mechanism of action and nursing care of adults receiving chimeric antigen receptor (CAR) T-cell therapy.

Data source: Peer reviewed articles and pharmaceutical drug labels.

Conclusion: CAR T-cell therapy is among the most exciting therapies in the evolution of cancer treatment. The efficacy of research with CAR T-cell therapy has shown promising results in hematologic malignancies as well as in solid tumors.

Implications for nursing practice: Understanding the complexity of care for these patients from the bedside to the outpatient setting is vital for their survival and quality of care.

Keywords: Axicabtagene ciloleucel; Chimeric antigen receptor (CAR) T cell; Cytokine release syndrome; Kymriah; Patient management; Tisagenlecleucel; Yescarta.