Drosophila melanogaster: a simple system for understanding complexity
- PMID: 31562251
- PMCID: PMC6826030
- DOI: 10.1242/dmm.041871
Drosophila melanogaster: a simple system for understanding complexity
Abstract
Understanding human gene function is fundamental to understanding and treating diseases. Research using the model organism Drosophila melanogaster benefits from a wealth of molecular genetic resources and information useful for efficient in vivo experimentation. Moreover, Drosophila offers a balance as a relatively simple organism that nonetheless exhibits complex multicellular activities. Recent examples demonstrate the power and continued promise of Drosophila research to further our understanding of conserved gene functions.
© 2019. Published by The Company of Biologists Ltd.
References
-
- Ali S. N., Dayarathna T. K., Ali A. N., Osumah T., Ahmed M., Cooper T. T., Power N. E., Zhang D., Kim D., Kim R. et al. (2018). Drosophila melanogaster as a function-based high-throughput screening model for antinephrolithiasis agents in kidney stone patients. Dis. Model. Mech. 11, dmm035873 10.1242/dmm.035873 - DOI - PMC - PubMed
-
- Bangi E., Ang C., Smibert P., Uzilov A. V., Teague A. G., Antipin Y., Chen R., Hecht C., Gruszczynski N., Yon W. J. et al. (2019). A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer. Sci. Adv. 5, eaav6528 10.1126/sciadv.aav6528 - DOI - PMC - PubMed
-
- Brand A. H. and Perrimon N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
