The Clinical Pharmacogenetics Implementation Consortium: 10 Years Later

Abstract

In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www.cpicpgx.org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB, http://www.pharmgkb.org) and the National Institutes of Health (NIH), was created to provide freely available, evidence-based, peer-reviewed, and updated pharmacogenetic clinical practice guidelines. To date, CPIC has published 23 guidelines (of which 11 have been updated), covering 19 genes and 46 drugs across several therapeutic areas. CPIC also now provides additional resources to facilitate the implementation of pharmacogenetics into routine clinical practice and the electronic health record. Furthermore, since its inception, CPIC's interactions with other resources, databases, websites, and genomic communities have grown. The purpose of this paper is to highlight the progress of CPIC over the past 10 years.

Figure 1.. CPIC interactions with PharmGKB and other resources, databases, websites and genomics communities. (Image used with permission from PharmGKB)

ACMG, American College of Medical Genetics and Genomics; ASCPT, American Society for Clinical Pharmacology & Therapeutics; ASHG, American Society of Human Genetics; ASHP, American Society of Health-System Pharmacists; ClinGen, Clinical Genome Resource; eMERGE, Electronic Medical Records and Genomics; FDA, Food and Drug Administration; GTR, Genetic Testing Registry; HGNC, HUGO Gene Nomenclature Committee; IGNITE, Implementing Genomics in Practice; LOINC, Logical Observation Identifiers Names and Codes; NCBI, National Center for Biotechnology Information; NCBO, National Center for Biomedical Ontology; PGRN, Pharmacogenomics Research Network; PharmVar, Pharmacogene Variation Consortium; SNOMED CT, Systematized Nomenclature of Medicine-Clinical Terms