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. 2019 Dec;80(12):1020-1025.
doi: 10.1016/j.humimm.2019.09.009. Epub 2019 Sep 25.

Th9 cytokines curb cervical cancer progression and immune evasion

Shilpa Raghuvanshi Chauhan  1 , Pallavi G Singhal  1 , Upma Sharma  1 , Kapil Bandil  1 , Kausik Chakraborty  2 , Mausumi Bharadwaj  3
Affiliations

Th9 cytokines curb cervical cancer progression and immune evasion

Shilpa Raghuvanshi Chauhan et al. Hum Immunol. 2019 Dec.

Erratum in

Abstract

Cervical cancer is one of the most common cancers among women in developing countries. Persistent infection with high-risk human papillomavirus (HPV) is the major determinant for the development of cervical cancer. Role of newly discovered T helper 9 (Th9) cells in cervical cancer pathogenesis is yet unfolded. In this study, we observed a huge infiltration of PU.1+ cells and overrepresentation of IL-9R in tissue biopsy specimens of CIN patients in cervical cancer cases. Treatment with Th9 signatory cytokines, IL-9 and IL-21, suppressed proliferation, enhanced apoptosis and stimulated the expression of MHC I and e-cadherin on HeLa cell lines. Th9 thus seems enhance antitumor immune response through T cell cytotoxicity and play crucial role in a controlling malignant cell transformation. Therefore, this study helps in firmer understanding of relevance of Th9 in cervical cancer immunity.

Keywords: Antitumor; Cervical cancer; IL-21; IL-9; PU.1(+) cells; TILs; Th9 cells.

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