Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan;158(2):368-388.
doi: 10.1053/j.gastro.2019.06.047. Epub 2019 Sep 26.

Chemoprevention of Colorectal Cancer

Bryson W Katona  1 , Jennifer M Weiss  2
Affiliations
Review

Chemoprevention of Colorectal Cancer

Bryson W Katona et al. Gastroenterology. 2020 Jan.

Abstract

Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from CRC, chemoprevention strategies have the potential to further reduce CRC incidence and mortality. Chemoprevention agents might be used for average-risk as well as high-risk groups, and to prevent CRC recurrence after therapy. CRC chemoprevention agents that have been studied include aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, statins, agents that target metabolic pathways, and vitamins and minerals. We review the prospect of chemoprevention of CRC, results from preclinical and human studies, challenges, and future directions.

Keywords: Adenoma; Chemoprevention; Colorectal Cancer.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Complexities of CRC chemoprevention. There are many factors to consider in evaluating CRC chemoprevention agents, including the intrinsic properties of the agent (side effects, cost, ease of administration), mechanisms of chemoprevention, and groups most likely to benefit with the least risk.
See this image and copyright information in PMC

References

    1. American Cancer Society. Global Cancer Facts & Figures 4th Edition American Cancer Society, 2018. Accessible at https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-....
    1. American Cancer Society. Cancer Facts & Figures 2019. American Cancer Society, 2019. Accessible at https://www.cancer.org/latest-news/facts-and-figures-2019.html.
    1. Schoen RE, Pinsky PF, Weissfeld JL, et al. Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med 2012;366:2345–57. - PMC - PubMed
    1. Nishihara R, Wu K, Lochhead P, et al. Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med 2013;369:1095–105. - PMC - PubMed
    1. Shaukat A, Mongin SJ, Geisser MS, et al. Long-term mortality after screening for colorectal cancer. N Engl J Med 2013;369:1106–14. - PubMed

Publication types

MeSH terms

Substances