Acne: Transient Arrest in the Homeostatic Host-Microbiota Dialog?

Andrea Szegedi¹, Zsolt Dajnoki², Tamás Bíró³, Lajos Kemény⁴, Dániel Törőcsik²

Affiliations

¹ Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address: aszegedi@med.unideb.hu.
² Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
³ Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
⁴ Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary; MTA-SZTE Dermatological Research Group, Szeged, Hungary.

PMID: 31564639
DOI: 10.1016/j.it.2019.08.006

Free article

Acne: Transient Arrest in the Homeostatic Host-Microbiota Dialog?

Andrea Szegedi et al. Trends Immunol. 2019 Oct.

Free article

. 2019 Oct;40(10):873-876.

doi: 10.1016/j.it.2019.08.006. Epub 2019 Sep 26.

Authors

Andrea Szegedi¹, Zsolt Dajnoki², Tamás Bíró³, Lajos Kemény⁴, Dániel Törőcsik²

Affiliations

¹ Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address: aszegedi@med.unideb.hu.
² Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
³ Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
⁴ Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary; MTA-SZTE Dermatological Research Group, Szeged, Hungary.

PMID: 31564639
DOI: 10.1016/j.it.2019.08.006

Abstract

We propose that acne vulgaris represents a naturally developing, transient inflammatory interaction of adolescent facial skin with its new microbial/chemical milieu (Cutibacterium acnes, sebum), replacing a state of previous childhood skin homeostasis. This concept might explain why acne is characterized by strong regional and age specificity, prevalent occurrence, and resolution.

Keywords: Cutibacterium acnes; acne; homeostasis; inflammation; microbiota; sebum.

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Acne: Transient Arrest in the Homeostatic Host-Microbiota Dialog?

Affiliations

Acne: Transient Arrest in the Homeostatic Host-Microbiota Dialog?

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Abstract

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