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. 2019 Sep 5:12:7289-7295.
doi: 10.2147/OTT.S223220. eCollection 2019.

KRAS rs7973450 A>G increases neuroblastoma risk in Chinese children: a four-center case-control study

Ao Lin #  1 , Rui-Xi Hua #  2 , Jue Tang #  1 , Jinhong Zhu  3 , Ruizhong Zhang  1 , Haixia Zhou  4 , Jiao Zhang  5 , Jiwen Cheng  6 , Huimin Xia  1 , Jing He  1
Affiliations

KRAS rs7973450 A>G increases neuroblastoma risk in Chinese children: a four-center case-control study

Ao Lin et al. Onco Targets Ther. .

Abstract

Background: Neuroblastoma is one of the most common extracranial solid pediatric tumors. KRAS plays an important role in regulating cell proliferation, differentiation, and apoptosis. Single nucleotide polymorphisms (SNPs) in KRAS have been shown to modify susceptibility to multiple tumors, but no specific molecular epidemiology study was reported regarding neuroblastoma.

Methods: We conducted a four-center case-control study to explore the association between KRAS gene polymorphisms (rs12587 G>T, rs7973450 A>G, rs7312175 G>A) and neuroblastoma susceptibility with 505 Chinese children and 1070 matched controls.

Results: We found that rs7973450 A>G was associated with significantly increased neuroblastoma risk [GG vs. AA: adjusted odds ratio (OR)=4.26, 95% confidence interval (CI)=1.28-14.19, P=0.018; GG vs. AA/AG: adjusted OR=4.27, 95% CI=1.28-14.24, P=0.018]. The stratified analysis further demonstrated that rs7973450 GG genotype carriers had a higher risk to develop neuroblastoma in the subgroups of males, tumor originated from the adrenal gland and clinical stages III+IV.

Conclusions: Overall, our results suggested that rs7973450 A>G was associated with increased neuroblastoma risk.

Keywords: KRAS; neuroblastoma; polymorphism; susceptibility.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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References

    1. Matthay KK, Maris JM, Schleiermacher G, et al. Neuroblastoma. Nat Rev Dis Primers. 2016;2:16078. doi:10.1038/nrdp.2016.78 - DOI - PubMed
    1. Bao PP, Li K, Wu CX, et al. [Recent incidences and trends of childhood malignant solid tumors in Shanghai, 2002-2010]. Zhonghua Er Ke Za Zhi. 2013;51(4):288–294. - PubMed
    1. London WB, Castleberry RP, Matthay KK, et al. Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children’s Oncology Group. J Clin Oncol. 2005;23(27):6459–6465. doi:10.1200/JCO.2005.05.571 - DOI - PubMed
    1. Cheung NK, Dyer MA. Neuroblastoma: developmental biology, cancer genomics and immunotherapy. Nat Rev Cancer. 2013;13(6):397–411. doi:10.1038/nrc3526 - DOI - PMC - PubMed
    1. Maris JM, Hogarty MD, Bagatell R, Cohn SL. Neuroblastoma. Lancet. 2007;369(9579):2106–2120. doi:10.1016/S0140-6736(07)60983-0 - DOI - PubMed