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. 2019 Nov 1;7(11):4491-4502.
doi: 10.1039/c9bm01039d. Epub 2019 Sep 30.

Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals

Aniruddha Adhikari  1 , Monojit Das  2 , Susmita Mondal  1 , Soumendra Darbar  3 , Anjan Kumar Das  4 , Siddhartha Sankar Bhattacharya  2 , Debasish Pal  2 , Samir Kumar Pal  5
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Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals

Aniruddha Adhikari et al. Biomater Sci. .

Erratum in

Abstract

Here, we have compared the behavioral neurotoxicity of a manganese nanoformulation (citrate functionalized Mn3O4 nanoparticles; C-Mn3O4 NPs) with that of the well-known neurotoxicant, ionic Mn, in an animal model. We found that mice administered with C-Mn3O4 NPs showed no signs of a neurobehavioral disorder, but the NPs instead ameliorated Mn-induced neurotoxicity (Parkinson's-like syndrome) through the chelation of excess Mn ions and subsequent reduction of oxidative damage.

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