Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma

David Corley Gibbs¹, Irene Orlow², Steven Vernali³, Helen B Powell³, Peter A Kanetsky⁴, Li Luo⁵, Klaus J Busam⁶, Ajay Sharma², Anne Kricker⁷, Bruce K Armstrong⁸, Anne E Cust⁹, Hoda Anton-Culver¹⁰, Stephen B Gruber¹¹, Richard P Gallagher¹², Roberto Zanetti¹³, Stefano Rosso¹³, Lidia Sacchetto¹⁴, Terence Dwyer¹⁵, David W Ollila¹⁶, Colin B Begg², Marianne Berwick⁵, Nancy E Thomas¹⁷; GEM Study Group

Collaborators, Affiliations

Collaborators

Affiliations

¹ Department of Epidemiology, Emory University, Atlanta, Georgia.
² Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
³ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina.
⁴ Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.
⁵ Department of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, New Mexico.
⁶ Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
⁷ Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
⁸ School of Public and Global Health, The University of Western Australia, Perth, Western Australia, Australia.
⁹ Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.
¹⁰ Department of Epidemiology, University of California, Irvine, Irvine, California.
¹¹ USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
¹² British Columbia Cancer and Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
¹³ Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy.
¹⁴ Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy; Politecnico di Torio, Turin, Italy; Universitá degli Studi di Torino, Turin, Italy.
¹⁵ George Institute for Global Health, Nuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, United Kingdom.
¹⁶ Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina; Department of Surgery, University of North Carolina, Chapel Hill, North Carolina.
¹⁷ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina. Electronic address: nthomas@med.unc.edu.

PMID: 31568773
PMCID: PMC7093215
DOI: 10.1016/j.jid.2019.09.006

Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma

David Corley Gibbs et al. J Invest Dermatol. 2020 Apr.

. 2020 Apr;140(4):918-922.e7.

doi: 10.1016/j.jid.2019.09.006. Epub 2019 Sep 27.

Authors

Collaborators

Affiliations

¹ Department of Epidemiology, Emory University, Atlanta, Georgia.
² Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
³ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina.
⁴ Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.
⁵ Department of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, New Mexico.
⁶ Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
⁷ Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
⁸ School of Public and Global Health, The University of Western Australia, Perth, Western Australia, Australia.
⁹ Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia; Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.
¹⁰ Department of Epidemiology, University of California, Irvine, Irvine, California.
¹¹ USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
¹² British Columbia Cancer and Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
¹³ Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy.
¹⁴ Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy; Politecnico di Torio, Turin, Italy; Universitá degli Studi di Torino, Turin, Italy.
¹⁵ George Institute for Global Health, Nuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, United Kingdom.
¹⁶ Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina; Department of Surgery, University of North Carolina, Chapel Hill, North Carolina.
¹⁷ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina. Electronic address: nthomas@med.unc.edu.

PMID: 31568773
PMCID: PMC7093215
DOI: 10.1016/j.jid.2019.09.006

No abstract available

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Conflict of interest statement

Conflict of Interest Statement: KJB has received minor royalties from editing a textbook with Elsevier. The remaining authors state no conflict of interest.

References

1. Begg CB, Hummer AJ, Mujumdar U, Armstrong BK, Kricker A, Marrett LD, et al. A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma. Int J Epidemiol 2006;35(3):756–64. - PubMed
1. Cole SR, Platt RW, Schisterman EF, Chu H, Westreich D, Richardson D, Poole C. Illustrating bias due to conditioning on a collider. Int J Epidemiol 2009;39(2):417–20. - PMC - PubMed
1. Chhabra Y, Yong HXL, Fane ME, Soogrim A, Lim W, Mahiuddin DN, et al. Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells. Pigment Cell Melanoma Res 2017. - PubMed
1. Duffy DL, Iles MM, Glass D, Zhu G, Barrett JH, Hoiom V, et al. IRF4 variants have age-specific effects on nevus count and predispose to melanoma. Am J Hum Genet 2010;87(1):6–16. - PMC - PubMed
1. Gibbs DC, Orlow I, Bramson JI, Kanetsky PA, Luo L, Kricker A, et al. Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways. J Natl Cancer Inst 2016;108(7). - PMC - PubMed

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Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma

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Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma

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Conflict of interest statement

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