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. 2019 Nov;30 Suppl 2(Suppl 2):S17-S27.
doi: 10.1097/EDE.0000000000001070.

The Relation of Birth Weight and Adiposity Across the Life Course to Semen Quality in Middle Age

Linda G Kahn  1 , Elizabeth M Widen  2 , Teresa Janevic  3 , Nadine Straka  4 , Xinhua Liu  5 , Piera M Cirillo  6 , Barbara A Cohn  6 , Germaine M Buck Louis  7 , Pam Factor-Litvak  8
Affiliations

The Relation of Birth Weight and Adiposity Across the Life Course to Semen Quality in Middle Age

Linda G Kahn et al. Epidemiology. 2019 Nov.

Abstract

Background: Studies of body mass index and semen quality have reported mixed results, but almost all were cross-sectional and many were conducted in selected populations. Longitudinal studies in population-based cohorts are necessary to identify how timing and duration of excess adiposity may affect semen quality.

Methods: In 193 members of the Child Health and Development Studies birth cohort, we examined associations of birth weight and adiposity at six time points spanning early childhood and adulthood with sperm concentration, motility, and morphology at mean age 44 years, as well as with corresponding 2010 World Health Organization (WHO) subfertility reference levels.

Results: Birth weight for gestational age percentile was positively associated with square-root sperm concentration (regression coefficient B [95% confidence interval] = 0.02 × 103 sperm/ml [0.004, 0.04]). Overweight/obesity in men's 20s was associated with lower percent progressive motility (B =-5.2 [-9.9, -0.63]), higher odds of low motility (odds ratio (OR) = 2.4 [1.3, 4.4]), and higher odds of poor morphology (OR = 1.9 [0.94, 3.8]). Those who were overweight/obese in their 20s were also more likely to meet two or three WHO subfertility criteria (OR = 3.9 [1.6, 9.4]) compared with normal-weight men. Each additional adult decade in which a participant was overweight/obese was associated with higher odds of low motility (OR = 1.3 [0.96, 1.6]) and higher odds of meeting two or three WHO subfertility criteria (OR = 1.5 [1.0, 2.2]).

Conclusions: In our data, associations among adiposity and sperm concentration, motility, and morphology varied according to timing and duration of exposure, potentially reflecting different biological mechanisms that influence these semen parameters.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

FIGURE.
FIGURE.
Participants in the 2005–2008 follow-up to the Child Health and Development Studies included in the current analysis. a Attempted contact b 160 participants provided two samples, 36 provided one
See this image and copyright information in PMC

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