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Observational Study
. 2009 Dec 15;55(6):26-31.
doi: 10.14341/probl200955626-31.

[Gender-specific features of hyperprolactinemia syndrome]

[Article in Russian]
G A Mel'nichenko  1 , L K Dzeranova  1 , I I Barmina  1 , E N Giniyatullina  1 , R V Rozhivanov  1 , A D Dobracheva  1 , N P Goncharov  1
Affiliations
Observational Study

[Gender-specific features of hyperprolactinemia syndrome]

[Article in Russian]
G A Mel'nichenko et al. Probl Endokrinol (Mosk). .

Abstract
in English, Russian

The objective of the present work was to study specific clinical features of hyperprolactinemia in men and women. A total of 148 men and 138 women with hyperprolactinemia of tumorous and non-tumorous etiology were examined. Analysis of medical histories demonstrated that the period between the appearance of the first clinical symptoms and the establishment of diagnosis of hyperprolactinemia in men was longer than in women. The frequency, size, and invasiveness of macroprolactinomas were also different in the two sexes. Prolactin-secreting pituitary tumours in men showed more aggressive growth than in women. All the patients included in the study were examined for the measurement of monomeric prolactin (PRL) by separation of individual fractions in the precipitation reaction with 25% polyethyleneglycol. Macroprolactinemia occurred more frequently in women than in men. Total and monomeric PRL levels were higher in men with hyperprolactinemia of tumorous origin compared with women.

В представленной работе изучали особенности течения гиперпролактинемии у мужчин и женщин. Обобщены результаты обследования 148 мужчин и 138 женщин с гиперпролактинемией опухолевого и неопухолевого генеза. Данные анамнеза заболевания показывают, что у мужчин первые клинические симптомы появляются позже, чем у женщин. Выявлено отличие по частоте встречаемости, размерам и инвазивности макропролактином: у мужчин пролактинсекретирующие опухоли гипофиза имеют более агрессивный характер роста. Всем пациентам было проведено исследование уровня мономерного пролактина (Прл) путем разделения фракций реакцией преципитации с 25% полиэтиленгликолем. Феномен макропролактинемии чаще отмечался у женщин. Уровень как общего, так и мономерного Прл был выше среди мужчин с гиперпролактинемией опухолевого генеза по сравнению с женщинами.

Keywords: hyperprolactinemia; pituitary adenoma; prolactin; sex differences.

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