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. 2019 Sep 9;63(12):e01470-19.
doi: 10.1128/AAC.01470-19. Epub 2019 Sep 30.

Demonstration of the broad spectrum in vitro activity of finafloxacin against pathogens of biodefence interest

Kay B Barnes  1 , Steven D Zumbrun  2 , Stephanie A Halasohoris  2 , Purvi D Desai  2 , Lynda L Miller  2 , Mark I Richards  1 , Paul Russell  1 , Christine Bentley  3 , Sarah V Harding  4
Affiliations

Demonstration of the broad spectrum in vitro activity of finafloxacin against pathogens of biodefence interest

Kay B Barnes et al. Antimicrob Agents Chemother. .

Abstract

This study investigated the in vitro activity of finafloxacin against panels of the biodefence pathogens. Broth microdilution assays were performed at neutral and acidic pH, to determine the effectiveness of the antibiotics in conditions typical of an intracellular environment. In all instances, finafloxacin demonstrated superior activity at low pH. These results highlight the importance of evaluating antimicrobial efficacy in conditions relevant to those encountered in vivo.

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Figures

FIG 1
FIG 1
Cumulative MICs determined for a panel of B. pseudomallei strains for finafloxacin (n = 21), ciprofloxacin (n = 11), and ceftazidime (n = 11) at pH 5 (A) and pH 7 (B).
See this image and copyright information in PMC

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