Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Sep 17:14:1657-1662.
doi: 10.2147/CIA.S218106. eCollection 2019.

Electrocardiographic left ventricular hypertrophy and mortality in an oldest-old hypertensive Chinese population

Rui Chen #  1 , Kunhao Bai #  2 , Fanghong Lu  3 , Yingxin Zhao  3 , Yujing Pan  4 , Fang Wang  1 , Luxia Zhang  1   5   6
Affiliations

Electrocardiographic left ventricular hypertrophy and mortality in an oldest-old hypertensive Chinese population

Rui Chen et al. Clin Interv Aging. .

Abstract

Purpose: Previous studies have identified that electrocardiographic pattern of left ventricular hypertrophy (ECG LVH) is associated with mortality, but studies of its correlation in the oldest-old hypertensive population is extremely limited. We investigated the correlation between ECG LVH and mortality in a hypertensive Chinese population aged 80 years and older.

Patients and methods: In this study, we included 284 Chinese participants older than 80 years. All included participants with hypertension (sitting systolic blood pressure [BP] 160 to 200 mmHg; sitting diastolic BP <110 mmHg) were ascertained at the baseline. ECG LVH was defined as a Sokolow-Lyon voltage calculated as the amplitude of SV1+ (max RV5 or RV6) greater than 3.5 mV. We categorized participants into two groups by the status of baseline ECG LVH. We used Cox regression models to calculate hazard ratio (HRs) for mortality due to ECG LVH, including cardiovascular mortality and all-cause mortality.

Results: In this study, with a 28-month median follow-up, a total of 35 (12.3%) patients died; 21 of those died due to cardiovascular causes. Compared with participants without ECG LVH, there was an increased risk of cardiovascular mortality in participants with ECG LVH (adjusted HR 4.25 [95% confidence interval [CI], 1.50-12.06]) but ECG LVH did not predict all-cause mortality (adjusted HR 2.31 [95% CI, 0.93-5.72]).

Conclusion: Our study shows that ECG LVH predicts the risk of cardiovascular mortality in an oldest-old hypertensive Chinese population.

Keywords: China; hypertension; left ventricular hypertrophy; mortality; oldest-old.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Cumulative survival curves of the two groups (n=284). Abbreviation: LVH, left ventricular hypertrophy.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Beard JR, Officer A, de Carvalho IA, et al. The world report on ageing and health: a policy framework for healthy ageing. Lancet. 2016;387(10033):2145–2154. doi:10.1016/S0140-6736(15)00516-4 - DOI - PMC - PubMed
    1. Dang JW, Wang YY, Liu NN. The Fourth Survey Report on the Living Conditions of China’s Urban and rural Older Persons; 2018.
    1. Li HZ, Yang X, Zhu Y, et al. The general research report of chinese strategic for dealing with population aging. Sci Res Aging. 2015;3(3):4–35.
    1. China NHaFPCo. China Health Statistics Yearbook 2013. National Health and Family Planning Commission of the People’s Republic of China; 2014.
    1. Kannel WB. Potency of vascular risk factors as the basis for antihypertensive therapy. Eur Heart J. 1992;13:34–42. doi:10.1093/eurheartj/13.suppl_g.34 - DOI - PubMed