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Comment
. 2019 Sep 12:10:2195.
doi: 10.3389/fimmu.2019.02195. eCollection 2019.

Commentary: Bettering BCG: a tough task for a TB vaccine?

Brahm S Srivastava  1 , Vipul K Singh  2 , Vivek K Kashyap  3 , Ranjana Srivastava  1 , Arshad Khan  2 , Chinnaswamy Jagannath  2
Affiliations
Comment

Commentary: Bettering BCG: a tough task for a TB vaccine?

Brahm S Srivastava et al. Front Immunol. .
No abstract available

Keywords: BCG—bacille calmette-guérin vaccine; LipY lipase from Mycobacterium tuberculosis; M. tuberculosis; booster antigen; vaccine.

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Figure 1
Figure 1
Potential role of LipY as a vaccine candidate for protection against tuberculosis.
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References

    1. Singh VK, Srivastava R, Srivastava BS. Manipulation of BCG vaccine: a double-edged sword. Eur J Clin Microbiol Infect Dis. (2016) 35:535–43. 10.1007/s10096-016-2579-y - DOI - PubMed
    1. Tameris MD, Hatherill M, Landry BS, Scriba TJ, Snowden MA, Lockhart S, et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet. (2013) 381:1021–8. 10.1016/S0140-6736(13)60177-4 - DOI - PMC - PubMed
    1. Bishai W, Sullivan Z, Bloom BR, Andersen P. Bettering BCG: a tough task for a TB vaccine? Nat Med. (2013) 19:410–1. 10.1038/nm.3153 - DOI - PubMed
    1. Singh VK, Srivastava V, Singh V, Rastogi N, Roy R, Shaw AK, et al. Overexpression of Rv3097c in Mycobacterium bovis BCG abolished the efficacy of BCG vaccine to protect against Mycobacterium tuberculosis infection in mice. Vaccine. (2011) 29:4754–60. 10.1016/j.vaccine.2011.04.086 - DOI - PubMed
    1. Singh VK, Srivastava M, Dasgupta A, Singh MP, Srivastava R, Srivastava BS. Increased virulence of Mycobacterium tuberculosis H37Rv overexpressing LipY in a murine model. Tuberculosis. (2014) 94:252–61. 10.1016/j.tube.2014.02.001 - DOI - PubMed

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